Assay Detail
Binding
CHEMBL2353206
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wnt signaling pathway in human HeLa cells assessed as inhibition of Wnt3a induced luciferase treated 30 mins before induction
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.24 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172104 | (Z)-3,4,3',5'-TETRAMETHOXYSTILBENE | — | 1 | 4.40 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.22 |
| CHEMBL44509 | (E)-3,4,3',5'-TETRAMETHOXYSTILBENE | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172104 | (Z)-3,4,3',5'-TETRAMETHOXYSTILBENE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL165 | RESVERATROL | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL44509 | (E)-3,4,3',5'-TETRAMETHOXYSTILBENE | IC50 | = | 80000.0 | nM | 4.10 |