Assay Detail
Functional
CHEMBL2353627
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.33 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228286 | (-)-ANTOFINE | — | 1 | 8.10 |
| CHEMBL244969 | (+/-)-ANTOFINE | — | 1 | 7.96 |
| CHEMBL2347592 | — | — | 1 | 7.28 |
| CHEMBL2347589 | — | — | 1 | 7.22 |
| CHEMBL2347590 | — | — | 1 | 6.10 |
| CHEMBL2347593 | — | — | 1 | - |
| CHEMBL2347591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228286 | (-)-ANTOFINE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL244969 | (+/-)-ANTOFINE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2347592 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2347589 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2347590 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2347593 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2347591 | — | IC50 | > | 1000.0 | nM | - |