Assay Detail
ADMET
CHEMBL2354055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP1A1 (unknown origin)-mediated deethylation of resorufin ethyl ether after 5 mins by spectrofluorimetric analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.66 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2347919 | — | — | 1 | 7.39 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 7.37 |
| CHEMBL26260 | BETA-NAPHTHOFLAVONE | — | 1 | 7.27 |
| CHEMBL2347912 | — | — | 1 | 6.96 |
| CHEMBL2347755 | — | — | 1 | 6.82 |
| CHEMBL2347756 | — | — | 1 | 6.57 |
| CHEMBL2347754 | — | — | 1 | 6.50 |
| CHEMBL2347911 | — | — | 1 | 6.46 |
| CHEMBL117 | CHRYSIN | — | 1 | 5.89 |
| CHEMBL16807 | 5-HYDROXYFLAVONE | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2347919 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL26260 | BETA-NAPHTHOFLAVONE | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL2347912 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2347755 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2347756 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2347754 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2347911 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL117 | CHRYSIN | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL16807 | 5-HYDROXYFLAVONE | IC50 | = | 4030.0 | nM | 5.39 |