Assay Detail
Functional
CHEMBL2363147
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SANGER: Inhibition of human CP50-MEL-B cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CP50-MEL-B |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.60 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 8.34 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.16 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.06 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.96 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.88 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.72 |
| CHEMBL3349342 | — | — | 1 | 7.67 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.46 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.36 |
| CHEMBL217354 | — | — | 1 | 7.16 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.14 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.11 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.09 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.08 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.06 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.89 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.76 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 6.53 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.20 |
| CHEMBL585951 | — | — | 1 | 6.14 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.11 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.05 |
| CHEMBL2363137 | — | — | 1 | 5.99 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.84 |
| CHEMBL477989 | SB590885 | — | 1 | 5.76 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 5.74 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.40 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 5.37 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.25 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 4.575 | nM | 8.34 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 6.929 | nM | 8.16 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 8.626 | nM | 8.06 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 13.12 | nM | 7.88 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 19.03 | nM | 7.72 |
| CHEMBL3349342 | — | IC50 | = | 21.54 | nM | 7.67 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 34.5 | nM | 7.46 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 43.44 | nM | 7.36 |
| CHEMBL217354 | — | IC50 | = | 69.59 | nM | 7.16 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 72.08 | nM | 7.14 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 77.4 | nM | 7.11 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 81.65 | nM | 7.09 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 83.68 | nM | 7.08 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 87.93 | nM | 7.06 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 127.94 | nM | 6.89 |
| CHEMBL105442 | CI-1040 | IC50 | = | 172.54 | nM | 6.76 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 297.84 | nM | 6.53 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 632.14 | nM | 6.20 |
| CHEMBL585951 | — | IC50 | = | 721.78 | nM | 6.14 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 780.03 | nM | 6.11 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 883.84 | nM | 6.05 |
| CHEMBL2363137 | — | IC50 | = | 1034.67 | nM | 5.99 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1433.36 | nM | 5.84 |
| CHEMBL477989 | SB590885 | IC50 | = | 1727.71 | nM | 5.76 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 1839.92 | nM | 5.74 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 3987.03 | nM | 5.40 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 4243.92 | nM | 5.37 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 5686.84 | nM | 5.25 |
| CHEMBL803 | CYTARABINE | IC50 | = | 5595.84 | nM | 5.25 |
| CHEMBL2134202 | — | IC50 | = | 9304.19 | nM | 5.03 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 9757.82 | nM | 5.01 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 9924.32 | nM | 5.00 |
| CHEMBL191384 | — | IC50 | = | 10499.23 | nM | 4.98 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 11566.99 | nM | 4.94 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 12292.46 | nM | 4.91 |
| CHEMBL188678 | — | IC50 | = | 13623.22 | nM | 4.87 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 14465.22 | nM | 4.84 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 14628.72 | nM | 4.83 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 17034.3 | nM | 4.77 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 20474.8 | nM | 4.69 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 21965.19 | nM | 4.66 |
| CHEMBL393929 | — | IC50 | = | 25739.87 | nM | 4.59 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 26567.51 | nM | 4.58 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 25990.13 | nM | 4.58 |
| CHEMBL1190711 | — | IC50 | = | 27574.57 | nM | 4.56 |
| CHEMBL939 | GEFITINIB | IC50 | = | 34659.23 | nM | 4.46 |
| CHEMBL577784 | BX-795 | IC50 | = | 34518.9 | nM | 4.46 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 34857.0 | nM | 4.46 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 36191.13 | nM | 4.44 |