Assay Detail
Functional
CHEMBL2363148
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SANGER: Inhibition of human CP66-MEL cell growth in a cell viability assay.
119
Total Activities
117
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CP66-MEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 119 | 5.46 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.32 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.52 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.44 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.93 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.65 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.35 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.31 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.26 |
| CHEMBL64925 | MG-132 | — | 2 | 7.12 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.10 |
| CHEMBL2144069 | — | — | 1 | 6.88 |
| CHEMBL514499 | GW843682X | — | 1 | 6.79 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.71 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.68 |
| CHEMBL2363137 | — | — | 1 | 6.57 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.50 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.50 |
| CHEMBL379300 | A-443654 | — | 1 | 6.34 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.31 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.21 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.19 |
| CHEMBL585951 | — | — | 1 | 6.09 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.06 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.02 |
| CHEMBL217354 | — | — | 1 | 5.92 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.77 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.70 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 5.64 |
| CHEMBL300389 | — | — | 1 | 5.63 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.4732 | nM | 9.32 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.004 | nM | 8.52 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 3.596 | nM | 8.44 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 11.67 | nM | 7.93 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 22.62 | nM | 7.65 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 45.08 | nM | 7.35 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 48.58 | nM | 7.31 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 55.15 | nM | 7.26 |
| CHEMBL64925 | MG-132 | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 78.87 | nM | 7.10 |
| CHEMBL2144069 | — | IC50 | = | 131.76 | nM | 6.88 |
| CHEMBL514499 | GW843682X | IC50 | = | 161.93 | nM | 6.79 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 195.31 | nM | 6.71 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 208.15 | nM | 6.68 |
| CHEMBL2363137 | — | IC50 | = | 268.06 | nM | 6.57 |
| CHEMBL513909 | BI-2536 | IC50 | = | 318.78 | nM | 6.50 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 314.15 | nM | 6.50 |
| CHEMBL379300 | A-443654 | IC50 | = | 459.12 | nM | 6.34 |
| CHEMBL105442 | CI-1040 | IC50 | = | 488.09 | nM | 6.31 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 609.69 | nM | 6.21 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 644.95 | nM | 6.19 |
| CHEMBL585951 | — | IC50 | = | 819.82 | nM | 6.09 |
| CHEMBL64925 | MG-132 | IC50 | = | 836.46 | nM | 6.08 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 871.1 | nM | 6.06 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 951.98 | nM | 6.02 |
| CHEMBL217354 | — | IC50 | = | 1203.29 | nM | 5.92 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1696.08 | nM | 5.77 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2017.67 | nM | 5.70 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 2290.14 | nM | 5.64 |
| CHEMBL300389 | — | IC50 | = | 2318.31 | nM | 5.63 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 2396.67 | nM | 5.62 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 2477.7 | nM | 5.61 |
| CHEMBL1090090 | VX-702 | IC50 | = | 2935.59 | nM | 5.53 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 3444.05 | nM | 5.46 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 3719.96 | nM | 5.43 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 3740.23 | nM | 5.43 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 3790.94 | nM | 5.42 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 4159.27 | nM | 5.38 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 4251.91 | nM | 5.37 |
| CHEMBL221137 | EMBELIN | IC50 | = | 4505.28 | nM | 5.35 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 6253.78 | nM | 5.20 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 9819.3 | nM | 5.01 |
| CHEMBL213100 | — | IC50 | = | 10646.85 | nM | 4.97 |
| CHEMBL803 | CYTARABINE | IC50 | = | 11980.59 | nM | 4.92 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 13641.0 | nM | 4.87 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 15468.8 | nM | 4.81 |
| CHEMBL573107 | — | IC50 | = | 17300.98 | nM | 4.76 |
| CHEMBL259181 | — | IC50 | = | 22791.23 | nM | 4.64 |
| CHEMBL1673039 | — | IC50 | = | 24995.65 | nM | 4.60 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 30477.48 | nM | 4.52 |