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Assay Detail

CHEMBL2363174

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
SANGER: Inhibition of human DB cell growth in a cell viability assay.
ChEMBL ↗
129
Total Activities
128
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type DB
Confidence 1 — Organism
Curated By Autocuration

Target

DB (CHEMBL2366331) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 129 5.52 8.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL65 CAMPTOTHECIN -1.0 1 8.94
CHEMBL159 VINBLASTINE 4.0 1 8.77
CHEMBL3545252 DOCETAXEL 4.0 1 8.75
CHEMBL96926 THAPSIGARGIN — 1 8.59
CHEMBL1201182 TEMSIROLIMUS 4.0 1 8.51
CHEMBL325041 BORTEZOMIB 3.0 1 8.47
CHEMBL94657 PATUPILONE 3.0 1 8.15
CHEMBL553025 VINORELBINE 4.0 1 7.71
CHEMBL34259 METHOTREXATE 4.0 1 7.67
CHEMBL1879463 DACTOLISIB 3.0 1 7.56
CHEMBL939 GEFITINIB 4.0 1 7.21
CHEMBL888 GEMCITABINE 4.0 1 7.07
CHEMBL300389 — — 1 6.86
CHEMBL1972860 ELESCLOMOL 3.0 1 6.85
CHEMBL53463 DOXORUBICIN 4.0 1 6.79
CHEMBL252164 LUMINESPIB 2.0 1 6.64
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.63
CHEMBL803 CYTARABINE 4.0 1 6.61
CHEMBL379300 A-443654 — 1 6.43
CHEMBL105 MITOMYCIN 4.0 1 6.37
CHEMBL512504 — — 1 6.31
CHEMBL1256459 TORIN1 — 1 6.30
CHEMBL1801204 AZD-8055 1.0 1 6.30
CHEMBL514499 GW843682X — 1 6.27
CHEMBL443684 NAVITOCLAX 3.0 1 6.24
CHEMBL98 VORINOSTAT 4.0 1 6.22
CHEMBL585951 — — 1 6.21
CHEMBL9470 SHIKONIN — 1 6.14
CHEMBL603469 LESTAURTINIB 3.0 1 6.10
CHEMBL428647 PACLITAXEL 4.0 1 6.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL65 CAMPTOTHECIN IC50 = 1.161 nM 8.94
CHEMBL159 VINBLASTINE IC50 = 1.687 nM 8.77
CHEMBL3545252 DOCETAXEL IC50 = 1.778 nM 8.75
CHEMBL96926 THAPSIGARGIN IC50 = 2.553 nM 8.59
CHEMBL1201182 TEMSIROLIMUS IC50 = 3.123 nM 8.51
CHEMBL325041 BORTEZOMIB IC50 = 3.409 nM 8.47
CHEMBL94657 PATUPILONE IC50 = 7.109 nM 8.15
CHEMBL553025 VINORELBINE IC50 = 19.41 nM 7.71
CHEMBL34259 METHOTREXATE IC50 = 21.28 nM 7.67
CHEMBL1879463 DACTOLISIB IC50 = 27.36 nM 7.56
CHEMBL939 GEFITINIB IC50 = 60.96 nM 7.21
CHEMBL888 GEMCITABINE IC50 = 84.4 nM 7.07
CHEMBL300389 — IC50 = 137.66 nM 6.86
CHEMBL1972860 ELESCLOMOL IC50 = 141.4 nM 6.85
CHEMBL53463 DOXORUBICIN IC50 = 161.71 nM 6.79
CHEMBL252164 LUMINESPIB IC50 = 228.65 nM 6.64
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 234.38 nM 6.63
CHEMBL803 CYTARABINE IC50 = 245.95 nM 6.61
CHEMBL379300 A-443654 IC50 = 374.8 nM 6.43
CHEMBL105 MITOMYCIN IC50 = 429.95 nM 6.37
CHEMBL512504 — IC50 = 488.93 nM 6.31
CHEMBL1801204 AZD-8055 IC50 = 500.21 nM 6.30
CHEMBL1256459 TORIN1 IC50 = 500.55 nM 6.30
CHEMBL514499 GW843682X IC50 = 538.29 nM 6.27
CHEMBL443684 NAVITOCLAX IC50 = 570.8 nM 6.24
CHEMBL98 VORINOSTAT IC50 = 598.57 nM 6.22
CHEMBL585951 — IC50 = 611.21 nM 6.21
CHEMBL9470 SHIKONIN IC50 = 726.29 nM 6.14
CHEMBL603469 LESTAURTINIB IC50 = 802.09 nM 6.10
CHEMBL428647 PACLITAXEL IC50 = 828.72 nM 6.08
CHEMBL449158 BRYOSTATIN 1 IC50 = 833.17 nM 6.08
CHEMBL189963 PALBOCICLIB IC50 = 1072.73 nM 5.97
CHEMBL608533 MIDOSTAURIN IC50 = 1219.29 nM 5.91
CHEMBL413 SIROLIMUS IC50 = 1272.42 nM 5.89
CHEMBL379975 — IC50 = 1297.34 nM 5.89
CHEMBL27759 ENTINOSTAT IC50 = 1703.53 nM 5.77
CHEMBL2041933 AZD-7762 IC50 = 1700.67 nM 5.77
CHEMBL577784 BX-795 IC50 = 2126.31 nM 5.67
CHEMBL11359 CISPLATIN IC50 = 2138.65 nM 5.67
CHEMBL288441 BOSUTINIB IC50 = 2428.69 nM 5.62
CHEMBL105442 CI-1040 IC50 = 2587.88 nM 5.59
CHEMBL573107 — IC50 = 2550.13 nM 5.59
CHEMBL109480 TANESPIMYCIN IC50 = 2977.59 nM 5.53
CHEMBL513909 BI-2536 IC50 = 3255.76 nM 5.49
CHEMBL521686 OLAPARIB IC50 = 3654.48 nM 5.44
CHEMBL38 TRETINOIN IC50 = 4765.19 nM 5.32
CHEMBL6067492 BLEOMYCIN IC50 = 5119.05 nM 5.29
CHEMBL202721 — IC50 = 6233.53 nM 5.21
CHEMBL507361 MIRDAMETINIB IC50 = 6353.19 nM 5.20
CHEMBL44657 ETOPOSIDE IC50 = 6529.8 nM 5.18