Assay Detail
Functional
CHEMBL2363185
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SANGER: Inhibition of human DOHH-2 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DOHH-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.95 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.22 |
| CHEMBL213100 | — | — | 1 | 9.22 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.74 |
| CHEMBL1256459 | TORIN1 | — | 1 | 8.65 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 8.47 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.30 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.20 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.08 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.92 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.85 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.77 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.76 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.70 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.67 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.65 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.64 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.63 |
| CHEMBL197603 | — | — | 1 | 7.41 |
| CHEMBL300389 | — | — | 1 | 7.39 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.33 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 7.32 |
| CHEMBL514499 | GW843682X | — | 1 | 7.22 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.03 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.88 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.75 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.73 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.73 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.71 |
| CHEMBL379300 | A-443654 | — | 1 | 6.62 |
| CHEMBL512504 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213100 | — | IC50 | = | 0.5969 | nM | 9.22 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.6022 | nM | 9.22 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.809 | nM | 8.74 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 2.247 | nM | 8.65 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 3.353 | nM | 8.47 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5.039 | nM | 8.30 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 6.303 | nM | 8.20 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 8.37 | nM | 8.08 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 12.03 | nM | 7.92 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 14.12 | nM | 7.85 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 16.82 | nM | 7.77 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 17.19 | nM | 7.76 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 19.99 | nM | 7.70 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 21.56 | nM | 7.67 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 22.26 | nM | 7.65 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 22.94 | nM | 7.64 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 23.45 | nM | 7.63 |
| CHEMBL197603 | — | IC50 | = | 39.07 | nM | 7.41 |
| CHEMBL300389 | — | IC50 | = | 40.85 | nM | 7.39 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 46.37 | nM | 7.33 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 48.03 | nM | 7.32 |
| CHEMBL514499 | GW843682X | IC50 | = | 60.78 | nM | 7.22 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 93.83 | nM | 7.03 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 130.64 | nM | 6.88 |
| CHEMBL513909 | BI-2536 | IC50 | = | 176.72 | nM | 6.75 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 184.43 | nM | 6.73 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 185.69 | nM | 6.73 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 195.64 | nM | 6.71 |
| CHEMBL379300 | A-443654 | IC50 | = | 240.02 | nM | 6.62 |
| CHEMBL512504 | — | IC50 | = | 245.13 | nM | 6.61 |
| CHEMBL509032 | TAE-684 | IC50 | = | 312.04 | nM | 6.51 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 328.05 | nM | 6.48 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 337.81 | nM | 6.47 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 347.33 | nM | 6.46 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 410.23 | nM | 6.39 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 706.68 | nM | 6.15 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 706.26 | nM | 6.15 |
| CHEMBL585951 | — | IC50 | = | 714.56 | nM | 6.15 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 793.3 | nM | 6.10 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 867.47 | nM | 6.06 |
| CHEMBL939 | GEFITINIB | IC50 | = | 1000.21 | nM | 6.00 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 1282.03 | nM | 5.89 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1378.6 | nM | 5.86 |
| CHEMBL202721 | — | IC50 | = | 1402.76 | nM | 5.85 |
| CHEMBL577784 | BX-795 | IC50 | = | 1458.14 | nM | 5.84 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 1717.82 | nM | 5.76 |
| CHEMBL2144069 | — | IC50 | = | 1987.28 | nM | 5.70 |
| CHEMBL1190711 | — | IC50 | = | 2031.95 | nM | 5.69 |
| CHEMBL535 | SUNITINIB | IC50 | = | 2334.31 | nM | 5.63 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 2422.79 | nM | 5.62 |