Assay Detail
Functional
CHEMBL2363189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human DU-4475 cell growth in a cell viability assay.
126
Total Activities
125
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-4475 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 126 | 5.98 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.87 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.62 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.51 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.50 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 8.45 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.22 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 8.03 |
| CHEMBL2144069 | — | — | 1 | 7.99 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.93 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.92 |
| CHEMBL3349342 | — | — | 1 | 7.74 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.67 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.65 |
| CHEMBL477989 | SB590885 | — | 1 | 7.63 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.51 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 7.47 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.37 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.32 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.32 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 7.13 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 7.12 |
| CHEMBL514499 | GW843682X | — | 1 | 7.10 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 7.09 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.04 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.02 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.01 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.98 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.95 |
| CHEMBL300389 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 1.363 | nM | 8.87 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 2.382 | nM | 8.62 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.024 | nM | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 3.067 | nM | 8.51 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 3.143 | nM | 8.50 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 3.566 | nM | 8.45 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 5.967 | nM | 8.22 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 9.438 | nM | 8.03 |
| CHEMBL2144069 | — | IC50 | = | 10.23 | nM | 7.99 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 11.73 | nM | 7.93 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL3349342 | — | IC50 | = | 18.34 | nM | 7.74 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 21.5 | nM | 7.67 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 22.61 | nM | 7.65 |
| CHEMBL477989 | SB590885 | IC50 | = | 23.54 | nM | 7.63 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 31.22 | nM | 7.51 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 33.67 | nM | 7.47 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 42.44 | nM | 7.37 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 47.47 | nM | 7.32 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 48.13 | nM | 7.32 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 74.57 | nM | 7.13 |
| CHEMBL105442 | CI-1040 | IC50 | = | 75.99 | nM | 7.12 |
| CHEMBL514499 | GW843682X | IC50 | = | 80.03 | nM | 7.10 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 80.47 | nM | 7.09 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 91.65 | nM | 7.04 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 96.15 | nM | 7.02 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 97.78 | nM | 7.01 |
| CHEMBL513909 | BI-2536 | IC50 | = | 104.07 | nM | 6.98 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 111.7 | nM | 6.95 |
| CHEMBL300389 | — | IC50 | = | 140.45 | nM | 6.85 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 161.62 | nM | 6.79 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 179.84 | nM | 6.75 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 187.68 | nM | 6.73 |
| CHEMBL64925 | MG-132 | IC50 | = | 196.58 | nM | 6.71 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 348.75 | nM | 6.46 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 383.01 | nM | 6.42 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 495.11 | nM | 6.30 |
| CHEMBL573107 | — | IC50 | = | 504.17 | nM | 6.30 |
| CHEMBL585951 | — | IC50 | = | 568.88 | nM | 6.25 |
| CHEMBL803 | CYTARABINE | IC50 | = | 575.4 | nM | 6.24 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 587.03 | nM | 6.23 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 654.27 | nM | 6.18 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 751.91 | nM | 6.12 |
| CHEMBL379300 | A-443654 | IC50 | = | 800.63 | nM | 6.10 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 1017.56 | nM | 5.99 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 1268.28 | nM | 5.90 |
| CHEMBL577784 | BX-795 | IC50 | = | 1292.45 | nM | 5.89 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1401.21 | nM | 5.85 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1458.53 | nM | 5.84 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1505.92 | nM | 5.82 |