Assay Detail
Functional
CHEMBL2363195
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SANGER: Inhibition of human EB-3 cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EB-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.41 | 8.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.58 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.72 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.44 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.28 |
| CHEMBL300389 | — | — | 1 | 7.19 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.01 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.76 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.65 |
| CHEMBL512504 | — | — | 1 | 6.53 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.52 |
| CHEMBL379300 | A-443654 | — | 1 | 6.48 |
| CHEMBL514499 | GW843682X | — | 1 | 6.46 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.36 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.21 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.11 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.02 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.94 |
| CHEMBL585951 | — | — | 1 | 5.74 |
| CHEMBL213100 | — | — | 1 | 5.67 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.50 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.40 |
| CHEMBL2363137 | — | — | 1 | 5.37 |
| CHEMBL64925 | MG-132 | — | 2 | 5.30 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 5.29 |
| CHEMBL509032 | TAE-684 | — | 1 | 5.29 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.25 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 5.15 |
| CHEMBL1190711 | — | — | 1 | 5.09 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.04 |
| CHEMBL180127 | SALUBRINAL | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 2.657 | nM | 8.58 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 18.96 | nM | 7.72 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 36.43 | nM | 7.44 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 52.67 | nM | 7.28 |
| CHEMBL300389 | — | IC50 | = | 64.78 | nM | 7.19 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 97.89 | nM | 7.01 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 173.1 | nM | 6.76 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 223.76 | nM | 6.65 |
| CHEMBL512504 | — | IC50 | = | 292.93 | nM | 6.53 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 299.79 | nM | 6.52 |
| CHEMBL379300 | A-443654 | IC50 | = | 334.39 | nM | 6.48 |
| CHEMBL514499 | GW843682X | IC50 | = | 350.97 | nM | 6.46 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 440.51 | nM | 6.36 |
| CHEMBL513909 | BI-2536 | IC50 | = | 611.53 | nM | 6.21 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 771.02 | nM | 6.11 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 956.55 | nM | 6.02 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1142.2 | nM | 5.94 |
| CHEMBL585951 | — | IC50 | = | 1834.62 | nM | 5.74 |
| CHEMBL213100 | — | IC50 | = | 2158.24 | nM | 5.67 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 3197.68 | nM | 5.50 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 3996.33 | nM | 5.40 |
| CHEMBL2363137 | — | IC50 | = | 4245.1 | nM | 5.37 |
| CHEMBL64925 | MG-132 | IC50 | = | 5030.41 | nM | 5.30 |
| CHEMBL509032 | TAE-684 | IC50 | = | 5175.04 | nM | 5.29 |
| CHEMBL591429 | PAC-1 | IC50 | = | 5123.13 | nM | 5.29 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 5597.68 | nM | 5.25 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 7072.33 | nM | 5.15 |
| CHEMBL1190711 | — | IC50 | = | 8057.96 | nM | 5.09 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 9102.61 | nM | 5.04 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 9625.72 | nM | 5.02 |
| CHEMBL472940 | — | IC50 | = | 10493.95 | nM | 4.98 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 11164.11 | nM | 4.95 |
| CHEMBL64925 | MG-132 | IC50 | = | 12448.5 | nM | 4.91 |
| CHEMBL515416 | — | IC50 | = | 15053.28 | nM | 4.82 |
| CHEMBL1242367 | — | IC50 | = | 17055.33 | nM | 4.77 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 17283.48 | nM | 4.76 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 17576.03 | nM | 4.75 |
| CHEMBL1673039 | — | IC50 | = | 17783.0 | nM | 4.75 |
| CHEMBL197603 | — | IC50 | = | 18793.97 | nM | 4.73 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 19506.51 | nM | 4.71 |
| CHEMBL221137 | EMBELIN | IC50 | = | 20778.4 | nM | 4.68 |
| CHEMBL2144069 | — | IC50 | = | 21856.16 | nM | 4.66 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 21833.14 | nM | 4.66 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 23183.11 | nM | 4.63 |
| CHEMBL135561 | — | IC50 | = | 23645.95 | nM | 4.63 |
| CHEMBL535 | SUNITINIB | IC50 | = | 29530.89 | nM | 4.53 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 34311.75 | nM | 4.46 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 36951.79 | nM | 4.43 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 40624.32 | nM | 4.39 |
| CHEMBL92309 | — | IC50 | = | 49579.18 | nM | 4.30 |