Assay Detail
Functional
CHEMBL2363196
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SANGER: Inhibition of human EB2 cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EB2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.75 | 8.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 8.93 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.70 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.43 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.17 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.98 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.74 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.47 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 7.25 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.18 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.14 |
| CHEMBL512504 | — | — | 1 | 6.85 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.51 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.41 |
| CHEMBL585951 | — | — | 1 | 6.24 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.16 |
| CHEMBL1190711 | — | — | 1 | 6.08 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 1 | 5.76 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.74 |
| CHEMBL300389 | — | — | 1 | 5.72 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.57 |
| CHEMBL1673039 | — | — | 1 | 5.55 |
| CHEMBL477772 | PAZOPANIB | 4.0 | 1 | 5.48 |
| CHEMBL514499 | GW843682X | — | 1 | 5.44 |
| CHEMBL472940 | — | — | 1 | 5.35 |
| CHEMBL64925 | MG-132 | — | 2 | 5.35 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 5.31 |
| CHEMBL221137 | EMBELIN | — | 1 | 5.21 |
| CHEMBL2144069 | — | — | 1 | 5.20 |
| CHEMBL258844 | — | — | 1 | 5.11 |
| CHEMBL379300 | A-443654 | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1.183 | nM | 8.93 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 2.012 | nM | 8.70 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 3.693 | nM | 8.43 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 10.43 | nM | 7.98 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 18.08 | nM | 7.74 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 33.73 | nM | 7.47 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 55.76 | nM | 7.25 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 65.36 | nM | 7.18 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 72.85 | nM | 7.14 |
| CHEMBL512504 | — | IC50 | = | 142.34 | nM | 6.85 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 310.95 | nM | 6.51 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 391.46 | nM | 6.41 |
| CHEMBL585951 | — | IC50 | = | 580.92 | nM | 6.24 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 691.03 | nM | 6.16 |
| CHEMBL1190711 | — | IC50 | = | 837.03 | nM | 6.08 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1750.19 | nM | 5.76 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1815.31 | nM | 5.74 |
| CHEMBL300389 | — | IC50 | = | 1912.88 | nM | 5.72 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 2718.29 | nM | 5.57 |
| CHEMBL1673039 | — | IC50 | = | 2819.04 | nM | 5.55 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 3281.68 | nM | 5.48 |
| CHEMBL514499 | GW843682X | IC50 | = | 3653.23 | nM | 5.44 |
| CHEMBL472940 | — | IC50 | = | 4491.42 | nM | 5.35 |
| CHEMBL64925 | MG-132 | IC50 | = | 4511.4 | nM | 5.35 |
| CHEMBL591429 | PAC-1 | IC50 | = | 4946.1 | nM | 5.31 |
| CHEMBL221137 | EMBELIN | IC50 | = | 6167.73 | nM | 5.21 |
| CHEMBL2144069 | — | IC50 | = | 6331.23 | nM | 5.20 |
| CHEMBL258844 | — | IC50 | = | 7754.68 | nM | 5.11 |
| CHEMBL379300 | A-443654 | IC50 | = | 9151.13 | nM | 5.04 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 9198.35 | nM | 5.04 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 9858.3 | nM | 5.01 |
| CHEMBL191384 | — | IC50 | = | 11543.21 | nM | 4.94 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 11996.82 | nM | 4.92 |
| CHEMBL513909 | BI-2536 | IC50 | = | 12688.06 | nM | 4.90 |
| CHEMBL64925 | MG-132 | IC50 | = | 13850.48 | nM | 4.86 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 17742.64 | nM | 4.75 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 20717.51 | nM | 4.68 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 31531.81 | nM | 4.50 |
| CHEMBL554 | LAPATINIB | IC50 | = | 36618.88 | nM | 4.44 |
| CHEMBL941 | IMATINIB | IC50 | = | 46698.96 | nM | 4.33 |
| CHEMBL135561 | — | IC50 | = | 54444.24 | nM | 4.26 |
| CHEMBL2363137 | — | IC50 | = | 63423.09 | nM | 4.20 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 67257.53 | nM | 4.17 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 70029.6 | nM | 4.16 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 85001.42 | nM | 4.07 |
| CHEMBL1643959 | — | IC50 | = | 94386.02 | nM | 4.03 |
| CHEMBL92309 | — | IC50 | = | 296610.85 | nM | - |
| CHEMBL228043 | — | IC50 | = | 1724740.7 | nM | - |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 113556.1 | nM | - |