Assay Detail
Functional
CHEMBL2363207
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SANGER: Inhibition of human EKVX cell growth in a cell viability assay.
138
Total Activities
136
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EKVX |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 138 | 5.25 | 8.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.67 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.47 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.40 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.34 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.27 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.00 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.98 |
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 6.78 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.60 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.56 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.54 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.46 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.36 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.35 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 6.35 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.26 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.22 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.17 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.10 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.06 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.05 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.00 |
| CHEMBL64925 | MG-132 | — | 2 | 5.99 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.99 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.99 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.95 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.94 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 5.87 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.78 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 2.136 | nM | 8.67 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 33.69 | nM | 7.47 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 39.51 | nM | 7.40 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 45.55 | nM | 7.34 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 53.84 | nM | 7.27 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 100.6 | nM | 7.00 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 104.83 | nM | 6.98 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 164.73 | nM | 6.78 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 250.47 | nM | 6.60 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 278.22 | nM | 6.56 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 287.08 | nM | 6.54 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 350.75 | nM | 6.46 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 436.37 | nM | 6.36 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 444.61 | nM | 6.35 |
| CHEMBL554 | LAPATINIB | IC50 | = | 448.74 | nM | 6.35 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 553.87 | nM | 6.26 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 605.98 | nM | 6.22 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 672.71 | nM | 6.17 |
| CHEMBL513909 | BI-2536 | IC50 | = | 790.73 | nM | 6.10 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 871.87 | nM | 6.06 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 893.0 | nM | 6.05 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1010.64 | nM | 6.00 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1031.21 | nM | 5.99 |
| CHEMBL64925 | MG-132 | IC50 | = | 1034.42 | nM | 5.99 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1012.9 | nM | 5.99 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 1123.54 | nM | 5.95 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1140.01 | nM | 5.94 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 1345.68 | nM | 5.87 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1656.18 | nM | 5.78 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 2001.54 | nM | 5.70 |
| CHEMBL939 | GEFITINIB | IC50 | = | 2049.39 | nM | 5.69 |
| CHEMBL401930 | — | IC50 | = | 2513.25 | nM | 5.60 |
| CHEMBL379300 | A-443654 | IC50 | = | 2565.65 | nM | 5.59 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 2688.57 | nM | 5.57 |
| CHEMBL585951 | — | IC50 | = | 2844.54 | nM | 5.55 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 3674.07 | nM | 5.43 |
| CHEMBL188678 | — | IC50 | = | 4225.24 | nM | 5.37 |
| CHEMBL3349342 | — | IC50 | = | 5011.21 | nM | 5.30 |
| CHEMBL514499 | GW843682X | IC50 | = | 6127.79 | nM | 5.21 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 6135.01 | nM | 5.21 |
| CHEMBL300389 | — | IC50 | = | 6163.17 | nM | 5.21 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 6463.21 | nM | 5.19 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 6971.25 | nM | 5.16 |
| CHEMBL217354 | — | IC50 | = | 7141.24 | nM | 5.15 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 7192.67 | nM | 5.14 |
| CHEMBL258844 | — | IC50 | = | 7268.02 | nM | 5.14 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 7168.65 | nM | 5.14 |
| CHEMBL2363137 | — | IC50 | = | 7560.52 | nM | 5.12 |
| CHEMBL509032 | TAE-684 | IC50 | = | 8470.66 | nM | 5.07 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 9129.41 | nM | 5.04 |