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Assay Detail

CHEMBL2363216

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Functional
SANGER: Inhibition of human ES8 cell growth in a cell viability assay.
ChEMBL ↗
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type ES8
Confidence 1 — Organism
Curated By Autocuration

Target

ES8 (CHEMBL2366069) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 139 5.84 9.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3545252 DOCETAXEL 4.0 1 9.59
CHEMBL325041 BORTEZOMIB 3.0 1 9.40
CHEMBL888 GEMCITABINE 4.0 1 9.11
CHEMBL65 CAMPTOTHECIN -1.0 1 9.10
CHEMBL1972860 ELESCLOMOL 3.0 1 8.88
CHEMBL94657 PATUPILONE 3.0 1 8.78
CHEMBL105 MITOMYCIN 4.0 1 8.77
CHEMBL553025 VINORELBINE 4.0 1 8.57
CHEMBL159 VINBLASTINE 4.0 1 8.49
CHEMBL1201182 TEMSIROLIMUS 4.0 1 8.28
CHEMBL428647 PACLITAXEL 4.0 1 8.27
CHEMBL514499 GW843682X — 1 7.98
CHEMBL1879463 DACTOLISIB 3.0 1 7.96
CHEMBL513909 BI-2536 2.0 1 7.83
CHEMBL96926 THAPSIGARGIN — 1 7.74
CHEMBL1256459 TORIN1 — 1 7.73
CHEMBL53463 DOXORUBICIN 4.0 1 7.68
CHEMBL252164 LUMINESPIB 2.0 1 7.45
CHEMBL572878 TOZASERTIB 2.0 1 7.34
CHEMBL575448 BMS-754807 2.0 1 7.00
CHEMBL2041933 AZD-7762 1.0 1 7.00
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.93
CHEMBL217354 — — 1 6.92
CHEMBL803 CYTARABINE 4.0 1 6.91
CHEMBL603469 LESTAURTINIB 3.0 1 6.88
CHEMBL585951 — — 1 6.87
CHEMBL44657 ETOPOSIDE 4.0 1 6.85
CHEMBL379300 A-443654 — 1 6.82
CHEMBL413 SIROLIMUS 4.0 1 6.65
CHEMBL64925 MG-132 — 2 6.61

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3545252 DOCETAXEL IC50 = 0.2599 nM 9.59
CHEMBL325041 BORTEZOMIB IC50 = 0.3999 nM 9.40
CHEMBL888 GEMCITABINE IC50 = 0.7802 nM 9.11
CHEMBL65 CAMPTOTHECIN IC50 = 0.7956 nM 9.10
CHEMBL1972860 ELESCLOMOL IC50 = 1.317 nM 8.88
CHEMBL94657 PATUPILONE IC50 = 1.649 nM 8.78
CHEMBL105 MITOMYCIN IC50 = 1.712 nM 8.77
CHEMBL553025 VINORELBINE IC50 = 2.719 nM 8.57
CHEMBL159 VINBLASTINE IC50 = 3.24 nM 8.49
CHEMBL1201182 TEMSIROLIMUS IC50 = 5.268 nM 8.28
CHEMBL428647 PACLITAXEL IC50 = 5.38 nM 8.27
CHEMBL514499 GW843682X IC50 = 10.46 nM 7.98
CHEMBL1879463 DACTOLISIB IC50 = 10.9 nM 7.96
CHEMBL513909 BI-2536 IC50 = 14.94 nM 7.83
CHEMBL96926 THAPSIGARGIN IC50 = 18.1 nM 7.74
CHEMBL1256459 TORIN1 IC50 = 18.44 nM 7.73
CHEMBL53463 DOXORUBICIN IC50 = 21.07 nM 7.68
CHEMBL252164 LUMINESPIB IC50 = 35.38 nM 7.45
CHEMBL572878 TOZASERTIB IC50 = 46.13 nM 7.34
CHEMBL2041933 AZD-7762 IC50 = 99.18 nM 7.00
CHEMBL575448 BMS-754807 IC50 = 100.16 nM 7.00
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 116.33 nM 6.93
CHEMBL217354 — IC50 = 119.27 nM 6.92
CHEMBL803 CYTARABINE IC50 = 123.93 nM 6.91
CHEMBL603469 LESTAURTINIB IC50 = 131.97 nM 6.88
CHEMBL585951 — IC50 = 134.65 nM 6.87
CHEMBL44657 ETOPOSIDE IC50 = 142.21 nM 6.85
CHEMBL379300 A-443654 IC50 = 151.13 nM 6.82
CHEMBL413 SIROLIMUS IC50 = 225.94 nM 6.65
CHEMBL64925 MG-132 IC50 = 247.63 nM 6.61
CHEMBL109480 TANESPIMYCIN IC50 = 307.84 nM 6.51
CHEMBL449158 BRYOSTATIN 1 IC50 = 312.22 nM 6.51
CHEMBL27759 ENTINOSTAT IC50 = 360.22 nM 6.44
CHEMBL1801204 AZD-8055 IC50 = 365.53 nM 6.44
CHEMBL300389 — IC50 = 409.94 nM 6.39
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 431.82 nM 6.37
CHEMBL202721 — IC50 = 498.06 nM 6.30
CHEMBL98 VORINOSTAT IC50 = 523.53 nM 6.28
CHEMBL34259 METHOTREXATE IC50 = 521.99 nM 6.28
CHEMBL507361 MIRDAMETINIB IC50 = 560.44 nM 6.25
CHEMBL189963 PALBOCICLIB IC50 = 605.21 nM 6.22
CHEMBL509032 TAE-684 IC50 = 749.75 nM 6.12
CHEMBL9470 SHIKONIN IC50 = 777.79 nM 6.11
CHEMBL521851 PICTILISIB IC50 = 810.52 nM 6.09
CHEMBL220241 GSK-269962A IC50 = 819.24 nM 6.09
CHEMBL577784 BX-795 IC50 = 843.36 nM 6.07
CHEMBL36 PYRIMETHAMINE IC50 = 896.67 nM 6.05
CHEMBL608533 MIDOSTAURIN IC50 = 1223.04 nM 5.91
CHEMBL6067492 BLEOMYCIN IC50 = 1398.53 nM 5.85
CHEMBL521686 OLAPARIB IC50 = 1724.14 nM 5.76