Assay Detail
Functional
CHEMBL2363217
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SANGER: Inhibition of human ESS-1 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ESS-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.68 | 10.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 10.54 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.75 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.82 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.31 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.15 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.12 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.04 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.96 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.86 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.14 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.10 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.99 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.87 |
| CHEMBL217354 | — | — | 1 | 6.85 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.79 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.73 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.61 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.54 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.32 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.28 |
| CHEMBL585951 | — | — | 1 | 6.18 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.17 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.99 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.97 |
| CHEMBL477772 | PAZOPANIB | 4.0 | 1 | 5.79 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.71 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.71 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.64 |
| CHEMBL379975 | — | — | 1 | 5.61 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.02858 | nM | 10.54 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.1787 | nM | 9.75 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.516 | nM | 8.82 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.876 | nM | 8.31 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 7.079 | nM | 8.15 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 7.585 | nM | 8.12 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 9.136 | nM | 8.04 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 11.09 | nM | 7.96 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 13.92 | nM | 7.86 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 72.46 | nM | 7.14 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 78.68 | nM | 7.10 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 102.14 | nM | 6.99 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 135.18 | nM | 6.87 |
| CHEMBL217354 | — | IC50 | = | 140.87 | nM | 6.85 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 164.13 | nM | 6.79 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 187.44 | nM | 6.73 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 248.05 | nM | 6.61 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 289.31 | nM | 6.54 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 478.21 | nM | 6.32 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 530.78 | nM | 6.28 |
| CHEMBL585951 | — | IC50 | = | 659.01 | nM | 6.18 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 682.3 | nM | 6.17 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1026.91 | nM | 5.99 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1076.18 | nM | 5.97 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 1603.96 | nM | 5.79 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1960.64 | nM | 5.71 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1930.6 | nM | 5.71 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2305.1 | nM | 5.64 |
| CHEMBL379975 | — | IC50 | = | 2483.88 | nM | 5.61 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 2542.38 | nM | 5.59 |
| CHEMBL1190711 | — | IC50 | = | 4076.4 | nM | 5.39 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4427.24 | nM | 5.35 |
| CHEMBL202721 | — | IC50 | = | 5077.96 | nM | 5.29 |
| CHEMBL1090090 | VX-702 | IC50 | = | 5291.79 | nM | 5.28 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 5255.97 | nM | 5.28 |
| CHEMBL803 | CYTARABINE | IC50 | = | 5478.51 | nM | 5.26 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 5978.69 | nM | 5.22 |
| CHEMBL191384 | — | IC50 | = | 6487.89 | nM | 5.19 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 6574.47 | nM | 5.18 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 6760.72 | nM | 5.17 |
| CHEMBL2363137 | — | IC50 | = | 7376.25 | nM | 5.13 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 8632.69 | nM | 5.06 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 8887.04 | nM | 5.05 |
| CHEMBL221137 | EMBELIN | IC50 | = | 9421.48 | nM | 5.03 |
| CHEMBL102714 | SB-216763 | IC50 | = | 9598.72 | nM | 5.02 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 9763.78 | nM | 5.01 |
| CHEMBL591429 | PAC-1 | IC50 | = | 10104.44 | nM | 5.00 |
| CHEMBL3349342 | — | IC50 | = | 10426.96 | nM | 4.98 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 12233.07 | nM | 4.91 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 14102.53 | nM | 4.85 |