Assay Detail
Functional
CHEMBL2363221
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SANGER: Inhibition of human EW-11 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EW-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.42 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.77 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.57 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.31 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.15 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.81 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.37 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.29 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.26 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.25 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.12 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.11 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.01 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.88 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.71 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 6.55 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.47 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.36 |
| CHEMBL217354 | — | — | 1 | 6.36 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.35 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.29 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.25 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.22 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 5.96 |
| CHEMBL585951 | — | — | 1 | 5.92 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.92 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.87 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.79 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 5.71 |
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | 5.65 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.686 | nM | 8.77 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 2.659 | nM | 8.57 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 4.896 | nM | 8.31 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 7.151 | nM | 8.15 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 42.68 | nM | 7.37 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 50.72 | nM | 7.29 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 54.78 | nM | 7.26 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 55.8 | nM | 7.25 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 75.35 | nM | 7.12 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 78.52 | nM | 7.11 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 96.88 | nM | 7.01 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 132.33 | nM | 6.88 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 195.6 | nM | 6.71 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 284.32 | nM | 6.55 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 341.56 | nM | 6.47 |
| CHEMBL217354 | — | IC50 | = | 434.17 | nM | 6.36 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 433.52 | nM | 6.36 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 447.16 | nM | 6.35 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 513.36 | nM | 6.29 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 563.26 | nM | 6.25 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 597.37 | nM | 6.22 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 1087.43 | nM | 5.96 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1213.88 | nM | 5.92 |
| CHEMBL585951 | — | IC50 | = | 1208.58 | nM | 5.92 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1360.26 | nM | 5.87 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1617.41 | nM | 5.79 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 1956.57 | nM | 5.71 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 2252.89 | nM | 5.65 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 3142.77 | nM | 5.50 |
| CHEMBL573107 | — | IC50 | = | 3412.24 | nM | 5.47 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 3630.22 | nM | 5.44 |
| CHEMBL939 | GEFITINIB | IC50 | = | 4132.61 | nM | 5.38 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 4418.38 | nM | 5.36 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 4522.31 | nM | 5.34 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 4765.65 | nM | 5.32 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 5080.72 | nM | 5.29 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 5180.99 | nM | 5.29 |
| CHEMBL300389 | — | IC50 | = | 5998.42 | nM | 5.22 |
| CHEMBL2144069 | — | IC50 | = | 6275.78 | nM | 5.20 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 6412.93 | nM | 5.19 |
| CHEMBL399530 | — | IC50 | = | 9171.45 | nM | 5.04 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 9176.53 | nM | 5.04 |
| CHEMBL1190711 | — | IC50 | = | 9503.76 | nM | 5.02 |
| CHEMBL509032 | TAE-684 | IC50 | = | 9653.96 | nM | 5.01 |
| CHEMBL577784 | BX-795 | IC50 | = | 10462.35 | nM | 4.98 |
| CHEMBL258844 | — | IC50 | = | 10752.55 | nM | 4.97 |
| CHEMBL209148 | — | IC50 | = | 10912.51 | nM | 4.96 |
| CHEMBL64925 | MG-132 | IC50 | = | 11518.61 | nM | 4.94 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 11669.4 | nM | 4.93 |