Assay Detail
Functional
CHEMBL2363224
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human EW-16 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EW-16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.89 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 10.64 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.92 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 9.51 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.22 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.97 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.87 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.79 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.72 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.56 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.36 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.16 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 8.16 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.13 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.11 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.92 |
| CHEMBL514499 | GW843682X | — | 1 | 7.88 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.87 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.74 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.68 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.67 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.57 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.54 |
| CHEMBL300389 | — | — | 1 | 7.48 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.41 |
| CHEMBL509032 | TAE-684 | — | 1 | 6.98 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 6.73 |
| CHEMBL217354 | — | — | 1 | 6.73 |
| CHEMBL401930 | — | — | 1 | 6.69 |
| CHEMBL379300 | A-443654 | — | 1 | 6.67 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.02299 | nM | 10.64 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.1214 | nM | 9.92 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.5984 | nM | 9.22 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.063 | nM | 8.97 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.348 | nM | 8.87 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 1.609 | nM | 8.79 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1.912 | nM | 8.72 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 2.751 | nM | 8.56 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 4.348 | nM | 8.36 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.937 | nM | 8.16 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 6.853 | nM | 8.16 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 7.49 | nM | 8.13 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 7.832 | nM | 8.11 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 11.92 | nM | 7.92 |
| CHEMBL514499 | GW843682X | IC50 | = | 13.25 | nM | 7.88 |
| CHEMBL513909 | BI-2536 | IC50 | = | 13.36 | nM | 7.87 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 18.04 | nM | 7.74 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 20.95 | nM | 7.68 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 21.48 | nM | 7.67 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 26.87 | nM | 7.57 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 28.57 | nM | 7.54 |
| CHEMBL300389 | — | IC50 | = | 32.8 | nM | 7.48 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 39.09 | nM | 7.41 |
| CHEMBL509032 | TAE-684 | IC50 | = | 105.68 | nM | 6.98 |
| CHEMBL217354 | — | IC50 | = | 185.28 | nM | 6.73 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 187.77 | nM | 6.73 |
| CHEMBL401930 | — | IC50 | = | 205.52 | nM | 6.69 |
| CHEMBL379300 | A-443654 | IC50 | = | 215.98 | nM | 6.67 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 225.59 | nM | 6.65 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 237.68 | nM | 6.62 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 245.49 | nM | 6.61 |
| CHEMBL803 | CYTARABINE | IC50 | = | 265.88 | nM | 6.58 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 299.15 | nM | 6.52 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 314.3 | nM | 6.50 |
| CHEMBL585951 | — | IC50 | = | 450.84 | nM | 6.35 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 537.74 | nM | 6.27 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 603.52 | nM | 6.22 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 761.78 | nM | 6.12 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 813.28 | nM | 6.09 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 894.75 | nM | 6.05 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1145.17 | nM | 5.94 |
| CHEMBL64925 | MG-132 | IC50 | = | 1313.47 | nM | 5.88 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1439.73 | nM | 5.84 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1438.42 | nM | 5.84 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 1550.83 | nM | 5.81 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1619.33 | nM | 5.79 |
| CHEMBL1190711 | — | IC50 | = | 1680.39 | nM | 5.78 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1741.07 | nM | 5.76 |
| CHEMBL209148 | — | IC50 | = | 1723.77 | nM | 5.76 |