Assay Detail
Functional
CHEMBL2363231
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SANGER: Inhibition of human FADU cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | FaDu |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.65 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.27 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 8.68 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.29 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.25 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.70 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.58 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.31 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.17 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.99 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.98 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.96 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.89 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.77 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.57 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.38 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.37 |
| CHEMBL217354 | — | — | 1 | 6.28 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.26 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.22 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.19 |
| CHEMBL585951 | — | — | 1 | 6.15 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.06 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.93 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.89 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.75 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.66 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 5.63 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.61 |
| CHEMBL399530 | — | — | 1 | 5.56 |
| CHEMBL379975 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.5392 | nM | 9.27 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 2.093 | nM | 8.68 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 5.104 | nM | 8.29 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 5.663 | nM | 8.25 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 20.02 | nM | 7.70 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 26.21 | nM | 7.58 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 48.52 | nM | 7.31 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 67.45 | nM | 7.17 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 102.18 | nM | 6.99 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 105.45 | nM | 6.98 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 108.77 | nM | 6.96 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 128.29 | nM | 6.89 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 168.78 | nM | 6.77 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 266.63 | nM | 6.57 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 411.72 | nM | 6.38 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 426.49 | nM | 6.37 |
| CHEMBL217354 | — | IC50 | = | 525.76 | nM | 6.28 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 544.04 | nM | 6.26 |
| CHEMBL939 | GEFITINIB | IC50 | = | 604.69 | nM | 6.22 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 647.9 | nM | 6.19 |
| CHEMBL585951 | — | IC50 | = | 715.04 | nM | 6.15 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 864.49 | nM | 6.06 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1185.47 | nM | 5.93 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1281.54 | nM | 5.89 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1766.39 | nM | 5.75 |
| CHEMBL803 | CYTARABINE | IC50 | = | 2169.98 | nM | 5.66 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 2322.96 | nM | 5.63 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2471.62 | nM | 5.61 |
| CHEMBL399530 | — | IC50 | = | 2729.24 | nM | 5.56 |
| CHEMBL379975 | — | IC50 | = | 3817.35 | nM | 5.42 |
| CHEMBL2363137 | — | IC50 | = | 4275.41 | nM | 5.37 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 4374.67 | nM | 5.36 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 4950.88 | nM | 5.30 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 5137.73 | nM | 5.29 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 5166.35 | nM | 5.29 |
| CHEMBL577784 | BX-795 | IC50 | = | 5152.42 | nM | 5.29 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 5278.37 | nM | 5.28 |
| CHEMBL105442 | CI-1040 | IC50 | = | 5557.26 | nM | 5.25 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 6289.16 | nM | 5.20 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 6260.39 | nM | 5.20 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 7509.3 | nM | 5.12 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 7894.69 | nM | 5.10 |
| CHEMBL188678 | — | IC50 | = | 8036.54 | nM | 5.09 |
| CHEMBL573107 | — | IC50 | = | 8175.43 | nM | 5.09 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 8384.02 | nM | 5.08 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 8915.43 | nM | 5.05 |
| CHEMBL202721 | — | IC50 | = | 12211.94 | nM | 4.91 |
| CHEMBL3349342 | — | IC50 | = | 13021.23 | nM | 4.88 |
| CHEMBL2134202 | — | IC50 | = | 13699.19 | nM | 4.86 |
| CHEMBL135561 | — | IC50 | = | 15222.9 | nM | 4.82 |