Assay Detail
Functional
CHEMBL2363241
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SANGER: Inhibition of human GDM-1 cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GDM-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.94 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.37 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.17 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.07 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 7.74 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.61 |
| CHEMBL512504 | — | — | 1 | 7.59 |
| CHEMBL514499 | GW843682X | — | 1 | 7.29 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.27 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.22 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.20 |
| CHEMBL477772 | PAZOPANIB | 4.0 | 1 | 6.98 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 6.86 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.80 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.76 |
| CHEMBL585951 | — | — | 1 | 6.69 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.66 |
| CHEMBL2144069 | — | — | 1 | 6.64 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.64 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.64 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.48 |
| CHEMBL64925 | MG-132 | — | 2 | 6.46 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.45 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.43 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.42 |
| CHEMBL509032 | TAE-684 | — | 1 | 6.33 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.21 |
| CHEMBL1190711 | — | — | 1 | 6.17 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.16 |
| CHEMBL558642 | GSK-650394 | — | 1 | 6.06 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 4.305 | nM | 8.37 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 6.77 | nM | 8.17 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 8.405 | nM | 8.07 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 18.33 | nM | 7.74 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 24.61 | nM | 7.61 |
| CHEMBL512504 | — | IC50 | = | 25.53 | nM | 7.59 |
| CHEMBL514499 | GW843682X | IC50 | = | 50.84 | nM | 7.29 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 53.38 | nM | 7.27 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 60.81 | nM | 7.22 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 62.54 | nM | 7.20 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 103.99 | nM | 6.98 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 136.72 | nM | 6.86 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 159.7 | nM | 6.80 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 172.62 | nM | 6.76 |
| CHEMBL585951 | — | IC50 | = | 204.15 | nM | 6.69 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 219.71 | nM | 6.66 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 230.23 | nM | 6.64 |
| CHEMBL2144069 | — | IC50 | = | 229.47 | nM | 6.64 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 228.45 | nM | 6.64 |
| CHEMBL513909 | BI-2536 | IC50 | = | 330.59 | nM | 6.48 |
| CHEMBL64925 | MG-132 | IC50 | = | 351.04 | nM | 6.46 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 352.39 | nM | 6.45 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 372.34 | nM | 6.43 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 377.46 | nM | 6.42 |
| CHEMBL509032 | TAE-684 | IC50 | = | 471.16 | nM | 6.33 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 614.09 | nM | 6.21 |
| CHEMBL1190711 | — | IC50 | = | 682.79 | nM | 6.17 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 684.94 | nM | 6.16 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 879.37 | nM | 6.06 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 886.87 | nM | 6.05 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 906.98 | nM | 6.04 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 2242.06 | nM | 5.65 |
| CHEMBL300389 | — | IC50 | = | 2339.78 | nM | 5.63 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 2489.94 | nM | 5.60 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 2676.06 | nM | 5.57 |
| CHEMBL259181 | — | IC50 | = | 3326.75 | nM | 5.48 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3402.06 | nM | 5.47 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 4246.17 | nM | 5.37 |
| CHEMBL591429 | PAC-1 | IC50 | = | 4638.87 | nM | 5.33 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 5417.81 | nM | 5.27 |
| CHEMBL2363137 | — | IC50 | = | 8370.58 | nM | 5.08 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 8391.96 | nM | 5.08 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 8972.92 | nM | 5.05 |
| CHEMBL379300 | A-443654 | IC50 | = | 9550.22 | nM | 5.02 |
| CHEMBL191384 | — | IC50 | = | 10482.39 | nM | 4.98 |
| CHEMBL258844 | — | IC50 | = | 17108.3 | nM | 4.77 |
| CHEMBL64925 | MG-132 | IC50 | = | 21046.85 | nM | 4.68 |
| CHEMBL535 | SUNITINIB | IC50 | = | 21941.42 | nM | 4.66 |
| CHEMBL941 | IMATINIB | IC50 | = | 22594.49 | nM | 4.65 |
| CHEMBL221137 | EMBELIN | IC50 | = | 28000.1 | nM | 4.55 |