Assay Detail
Functional
CHEMBL2363243
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SANGER: Inhibition of human GI-ME-N cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GI-ME-N |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.59 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.20 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.45 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.24 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.22 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.22 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.74 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.52 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.47 |
| CHEMBL220241 | GSK-269962A | — | 1 | 7.30 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.21 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.20 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.14 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.13 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.07 |
| CHEMBL514499 | GW843682X | — | 1 | 7.05 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.03 |
| CHEMBL300389 | — | — | 1 | 6.98 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.83 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.76 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.74 |
| CHEMBL64925 | MG-132 | — | 2 | 6.71 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.71 |
| CHEMBL379300 | A-443654 | — | 1 | 6.55 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.54 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.42 |
| CHEMBL217354 | — | — | 1 | 6.39 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.36 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.34 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.34 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.6343 | nM | 9.20 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.577 | nM | 8.45 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5.755 | nM | 8.24 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 6.085 | nM | 8.22 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 6.076 | nM | 8.22 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 18.22 | nM | 7.74 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 29.91 | nM | 7.52 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 33.89 | nM | 7.47 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 49.51 | nM | 7.30 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 61.18 | nM | 7.21 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 63.57 | nM | 7.20 |
| CHEMBL513909 | BI-2536 | IC50 | = | 72.86 | nM | 7.14 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 74.26 | nM | 7.13 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 84.52 | nM | 7.07 |
| CHEMBL514499 | GW843682X | IC50 | = | 88.27 | nM | 7.05 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 93.33 | nM | 7.03 |
| CHEMBL300389 | — | IC50 | = | 105.41 | nM | 6.98 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 147.16 | nM | 6.83 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 173.73 | nM | 6.76 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 180.2 | nM | 6.74 |
| CHEMBL64925 | MG-132 | IC50 | = | 193.06 | nM | 6.71 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 194.75 | nM | 6.71 |
| CHEMBL379300 | A-443654 | IC50 | = | 278.39 | nM | 6.55 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 290.33 | nM | 6.54 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 379.33 | nM | 6.42 |
| CHEMBL217354 | — | IC50 | = | 403.18 | nM | 6.39 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 440.79 | nM | 6.36 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 454.31 | nM | 6.34 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 454.6 | nM | 6.34 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 551.75 | nM | 6.26 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 553.84 | nM | 6.26 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 630.69 | nM | 6.20 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 772.35 | nM | 6.11 |
| CHEMBL1673039 | — | IC50 | = | 889.07 | nM | 6.05 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1028.27 | nM | 5.99 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1252.08 | nM | 5.90 |
| CHEMBL2144069 | — | IC50 | = | 1292.12 | nM | 5.89 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1390.89 | nM | 5.86 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 1402.72 | nM | 5.85 |
| CHEMBL585951 | — | IC50 | = | 1441.19 | nM | 5.84 |
| CHEMBL379975 | — | IC50 | = | 1528.75 | nM | 5.82 |
| CHEMBL3349342 | — | IC50 | = | 1583.91 | nM | 5.80 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1659.67 | nM | 5.78 |
| CHEMBL577784 | BX-795 | IC50 | = | 1865.3 | nM | 5.73 |
| CHEMBL401930 | — | IC50 | = | 2059.68 | nM | 5.69 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 2108.51 | nM | 5.68 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 2281.23 | nM | 5.64 |
| CHEMBL197603 | — | IC50 | = | 2291.98 | nM | 5.64 |
| CHEMBL515416 | — | IC50 | = | 2518.16 | nM | 5.60 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 3005.65 | nM | 5.52 |