Assay Detail
Functional
CHEMBL2363255
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SANGER: Inhibition of human HCC1187 cell growth in a cell viability assay.
135
Total Activities
133
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC1187 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 135 | 5.14 | 8.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.56 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.45 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.86 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.72 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.64 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.10 |
| CHEMBL514499 | GW843682X | — | 1 | 6.92 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.51 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.50 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.48 |
| CHEMBL217354 | — | — | 1 | 6.37 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.33 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.30 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.24 |
| CHEMBL585951 | — | — | 1 | 6.23 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.23 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.01 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.00 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.99 |
| CHEMBL379300 | A-443654 | — | 1 | 5.95 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 5.81 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.77 |
| CHEMBL191384 | — | — | 1 | 5.74 |
| CHEMBL509032 | TAE-684 | — | 1 | 5.73 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.65 |
| CHEMBL577784 | BX-795 | — | 1 | 5.54 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 5.42 |
| CHEMBL2144069 | — | — | 1 | 5.39 |
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 5.38 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 2.754 | nM | 8.56 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 3.536 | nM | 8.45 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 13.86 | nM | 7.86 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 19.24 | nM | 7.72 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 22.63 | nM | 7.64 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 79.33 | nM | 7.10 |
| CHEMBL514499 | GW843682X | IC50 | = | 121.63 | nM | 6.92 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 307.25 | nM | 6.51 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 314.07 | nM | 6.50 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 334.04 | nM | 6.48 |
| CHEMBL217354 | — | IC50 | = | 424.97 | nM | 6.37 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 467.68 | nM | 6.33 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 505.2 | nM | 6.30 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 575.83 | nM | 6.24 |
| CHEMBL585951 | — | IC50 | = | 594.19 | nM | 6.23 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 591.47 | nM | 6.23 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 967.49 | nM | 6.01 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 1005.05 | nM | 6.00 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1019.79 | nM | 5.99 |
| CHEMBL379300 | A-443654 | IC50 | = | 1130.72 | nM | 5.95 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 1555.22 | nM | 5.81 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1705.45 | nM | 5.77 |
| CHEMBL191384 | — | IC50 | = | 1811.39 | nM | 5.74 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1862.41 | nM | 5.73 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 2216.41 | nM | 5.65 |
| CHEMBL577784 | BX-795 | IC50 | = | 2896.77 | nM | 5.54 |
| CHEMBL513909 | BI-2536 | IC50 | = | 3783.15 | nM | 5.42 |
| CHEMBL2144069 | — | IC50 | = | 4033.07 | nM | 5.39 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 4215.97 | nM | 5.38 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 4896.57 | nM | 5.31 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 5096.38 | nM | 5.29 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 5810.08 | nM | 5.24 |
| CHEMBL939 | GEFITINIB | IC50 | = | 5710.32 | nM | 5.24 |
| CHEMBL300389 | — | IC50 | = | 5839.5 | nM | 5.23 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 7613.6 | nM | 5.12 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 7907.46 | nM | 5.10 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 8293.91 | nM | 5.08 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 8921.3 | nM | 5.05 |
| CHEMBL512504 | — | IC50 | = | 11477.65 | nM | 4.94 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 11858.77 | nM | 4.93 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 12204.09 | nM | 4.91 |
| CHEMBL399530 | — | IC50 | = | 12833.73 | nM | 4.89 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 13191.25 | nM | 4.88 |
| CHEMBL64925 | MG-132 | IC50 | = | 13834.89 | nM | 4.86 |
| CHEMBL573107 | — | IC50 | = | 16655.72 | nM | 4.78 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 16651.16 | nM | 4.78 |
| CHEMBL401930 | — | IC50 | = | 16643.77 | nM | 4.78 |
| CHEMBL535 | SUNITINIB | IC50 | = | 18018.75 | nM | 4.74 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 19179.62 | nM | 4.72 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 18844.55 | nM | 4.72 |