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Assay Detail

CHEMBL2363259

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Functional
SANGER: Inhibition of human HCC1599 cell growth in a cell viability assay.
ChEMBL ↗
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCC1599
Confidence 1 — Organism
Curated By Autocuration

Target

HCC1599 (CHEMBL2366063) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 78 5.71 7.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL553025 VINORELBINE 4.0 1 7.98
CHEMBL325041 BORTEZOMIB 3.0 1 7.92
CHEMBL94657 PATUPILONE 3.0 1 7.92
CHEMBL514499 GW843682X — 1 7.73
CHEMBL428647 PACLITAXEL 4.0 1 7.70
CHEMBL513909 BI-2536 2.0 1 7.37
CHEMBL300389 — — 1 7.36
CHEMBL1256459 TORIN1 — 1 7.31
CHEMBL888 GEMCITABINE 4.0 1 7.15
CHEMBL53463 DOXORUBICIN 4.0 1 7.14
CHEMBL252164 LUMINESPIB 2.0 1 7.02
CHEMBL105 MITOMYCIN 4.0 1 6.92
CHEMBL379300 A-443654 — 1 6.79
CHEMBL96926 THAPSIGARGIN — 1 6.71
CHEMBL413 SIROLIMUS 4.0 1 6.58
CHEMBL512504 — — 1 6.55
CHEMBL9470 SHIKONIN — 1 6.41
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.34
CHEMBL585951 — — 1 6.33
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.30
CHEMBL27759 ENTINOSTAT 3.0 1 6.29
CHEMBL44657 ETOPOSIDE 4.0 1 6.21
CHEMBL572878 TOZASERTIB 2.0 1 6.09
CHEMBL608533 MIDOSTAURIN 4.0 1 6.06
CHEMBL392695 S-TRITYL-L-CYSTEINE — 1 5.91
CHEMBL64925 MG-132 — 2 5.90
CHEMBL515416 — — 1 5.66
CHEMBL1190711 — — 1 5.57
CHEMBL6067492 BLEOMYCIN 4.0 1 5.47
CHEMBL2144069 — — 1 5.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL553025 VINORELBINE IC50 = 10.57 nM 7.98
CHEMBL94657 PATUPILONE IC50 = 11.89 nM 7.92
CHEMBL325041 BORTEZOMIB IC50 = 11.91 nM 7.92
CHEMBL514499 GW843682X IC50 = 18.45 nM 7.73
CHEMBL428647 PACLITAXEL IC50 = 20.2 nM 7.70
CHEMBL513909 BI-2536 IC50 = 42.58 nM 7.37
CHEMBL300389 — IC50 = 43.87 nM 7.36
CHEMBL1256459 TORIN1 IC50 = 48.79 nM 7.31
CHEMBL888 GEMCITABINE IC50 = 70.22 nM 7.15
CHEMBL53463 DOXORUBICIN IC50 = 72.45 nM 7.14
CHEMBL252164 LUMINESPIB IC50 = 96.01 nM 7.02
CHEMBL105 MITOMYCIN IC50 = 120.17 nM 6.92
CHEMBL379300 A-443654 IC50 = 162.28 nM 6.79
CHEMBL96926 THAPSIGARGIN IC50 = 194.05 nM 6.71
CHEMBL413 SIROLIMUS IC50 = 261.47 nM 6.58
CHEMBL512504 — IC50 = 278.41 nM 6.55
CHEMBL9470 SHIKONIN IC50 = 388.27 nM 6.41
CHEMBL449158 BRYOSTATIN 1 IC50 = 451.94 nM 6.34
CHEMBL585951 — IC50 = 465.73 nM 6.33
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 499.55 nM 6.30
CHEMBL27759 ENTINOSTAT IC50 = 515.7 nM 6.29
CHEMBL44657 ETOPOSIDE IC50 = 616.27 nM 6.21
CHEMBL572878 TOZASERTIB IC50 = 808.74 nM 6.09
CHEMBL608533 MIDOSTAURIN IC50 = 879.1 nM 6.06
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 1228.36 nM 5.91
CHEMBL64925 MG-132 IC50 = 1255.89 nM 5.90
CHEMBL515416 — IC50 = 2172.11 nM 5.66
CHEMBL1190711 — IC50 = 2693.36 nM 5.57
CHEMBL6067492 BLEOMYCIN IC50 = 3368.75 nM 5.47
CHEMBL2144069 — IC50 = 4801.7 nM 5.32
CHEMBL535 SUNITINIB IC50 = 8199.87 nM 5.09
CHEMBL221137 EMBELIN IC50 = 9037.11 nM 5.04
CHEMBL135561 — IC50 = 11357.77 nM 4.95
CHEMBL1673039 — IC50 = 11894.08 nM 4.92
CHEMBL180127 SALUBRINAL IC50 = 12109.42 nM 4.92
CHEMBL601719 CRIZOTINIB IC50 = 12906.93 nM 4.89
CHEMBL14762 SELICICLIB IC50 = 14597.5 nM 4.84
CHEMBL2363137 — IC50 = 16670.57 nM 4.78
CHEMBL509032 TAE-684 IC50 = 19644.75 nM 4.71
CHEMBL258844 — IC50 = 20731.12 nM 4.68
CHEMBL259181 — IC50 = 23801.68 nM 4.62
CHEMBL591429 PAC-1 IC50 = 25712.44 nM 4.59
CHEMBL575448 BMS-754807 IC50 = 29234.95 nM 4.53
CHEMBL5416410 DASATINIB IC50 = 32332.47 nM 4.49
CHEMBL1171837 PONATINIB IC50 = 37161.75 nM 4.43
CHEMBL217092 SARACATINIB IC50 = 36705.33 nM 4.43
CHEMBL220241 GSK-269962A IC50 = 37601.05 nM 4.42
CHEMBL191384 — IC50 = 38799.52 nM 4.41
CHEMBL36 PYRIMETHAMINE IC50 = 38506.0 nM 4.41
CHEMBL409 BICALUTAMIDE IC50 = 49542.56 nM 4.30