Assay Detail
Functional
CHEMBL2363264
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SANGER: Inhibition of human HCC2218 cell growth in a cell viability assay.
122
Total Activities
121
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC2218 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 122 | 5.58 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 8.18 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 8.01 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.71 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.60 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.51 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.42 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.30 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 7.27 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.26 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.24 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.23 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.10 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.80 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.74 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.68 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.66 |
| CHEMBL379300 | A-443654 | — | 1 | 6.58 |
| CHEMBL512504 | — | — | 1 | 6.47 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.33 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.30 |
| CHEMBL1090090 | VX-702 | 2.0 | 1 | 6.30 |
| CHEMBL514499 | GW843682X | — | 1 | 6.24 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.23 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.18 |
| CHEMBL300389 | — | — | 1 | 6.15 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.10 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 6.06 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.02 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 6.608 | nM | 8.18 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 9.869 | nM | 8.01 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 24.94 | nM | 7.60 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 30.8 | nM | 7.51 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 37.9 | nM | 7.42 |
| CHEMBL939 | GEFITINIB | IC50 | = | 50.59 | nM | 7.30 |
| CHEMBL554 | LAPATINIB | IC50 | = | 53.26 | nM | 7.27 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 55.5 | nM | 7.26 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 57.06 | nM | 7.24 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 58.94 | nM | 7.23 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 79.26 | nM | 7.10 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 99.99 | nM | 7.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 159.8 | nM | 6.80 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 181.66 | nM | 6.74 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 206.88 | nM | 6.68 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 220.93 | nM | 6.66 |
| CHEMBL379300 | A-443654 | IC50 | = | 266.09 | nM | 6.58 |
| CHEMBL512504 | — | IC50 | = | 341.8 | nM | 6.47 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 472.27 | nM | 6.33 |
| CHEMBL1090090 | VX-702 | IC50 | = | 497.28 | nM | 6.30 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 496.03 | nM | 6.30 |
| CHEMBL514499 | GW843682X | IC50 | = | 576.71 | nM | 6.24 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 588.82 | nM | 6.23 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 656.2 | nM | 6.18 |
| CHEMBL300389 | — | IC50 | = | 710.22 | nM | 6.15 |
| CHEMBL513909 | BI-2536 | IC50 | = | 791.31 | nM | 6.10 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 878.44 | nM | 6.06 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 958.48 | nM | 6.02 |
| CHEMBL477989 | SB590885 | IC50 | = | 1059.13 | nM | 5.97 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1073.81 | nM | 5.97 |
| CHEMBL585951 | — | IC50 | = | 1085.96 | nM | 5.96 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1166.41 | nM | 5.93 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 1682.25 | nM | 5.77 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 2353.74 | nM | 5.63 |
| CHEMBL189584 | PD-173074 | IC50 | = | 2379.39 | nM | 5.62 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 2408.09 | nM | 5.62 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 2484.87 | nM | 5.61 |
| CHEMBL105442 | CI-1040 | IC50 | = | 2647.78 | nM | 5.58 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 3120.03 | nM | 5.51 |
| CHEMBL64925 | MG-132 | IC50 | = | 3469.37 | nM | 5.46 |
| CHEMBL2363137 | — | IC50 | = | 3441.55 | nM | 5.46 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 3731.03 | nM | 5.43 |
| CHEMBL240954 | — | IC50 | = | 3837.08 | nM | 5.42 |
| CHEMBL591429 | PAC-1 | IC50 | = | 4328.45 | nM | 5.36 |
| CHEMBL64925 | MG-132 | IC50 | = | 4448.12 | nM | 5.35 |
| CHEMBL202721 | — | IC50 | = | 4631.95 | nM | 5.33 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 7200.89 | nM | 5.14 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 7629.7 | nM | 5.12 |
| CHEMBL506871 | VELIPARIB | IC50 | = | 7797.04 | nM | 5.11 |