Assay Detail
Functional
CHEMBL2363265
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SANGER: Inhibition of human HCC2998 cell growth in a cell viability assay.
114
Total Activities
113
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC 2998 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 114 | 5.80 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.89 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.38 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.98 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 8.47 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.39 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.30 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.20 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 8.18 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.76 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.70 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.53 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.47 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.14 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.13 |
| CHEMBL3349342 | — | — | 1 | 7.06 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.96 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.93 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.82 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.80 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.67 |
| CHEMBL2144069 | — | — | 1 | 6.65 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.57 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.50 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.42 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.26 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.11 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 6.05 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 6.05 |
| CHEMBL64925 | MG-132 | — | 1 | 6.03 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.1274 | nM | 9.89 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.4121 | nM | 9.38 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.051 | nM | 8.98 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 3.348 | nM | 8.47 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 4.077 | nM | 8.39 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5.045 | nM | 8.30 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 6.339 | nM | 8.20 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 6.592 | nM | 8.18 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 17.44 | nM | 7.76 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 19.83 | nM | 7.70 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 29.45 | nM | 7.53 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 33.66 | nM | 7.47 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 71.9 | nM | 7.14 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 73.47 | nM | 7.13 |
| CHEMBL3349342 | — | IC50 | = | 86.85 | nM | 7.06 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 110.66 | nM | 6.96 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 117.92 | nM | 6.93 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 150.28 | nM | 6.82 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 160.13 | nM | 6.80 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 211.57 | nM | 6.67 |
| CHEMBL2144069 | — | IC50 | = | 221.87 | nM | 6.65 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 269.07 | nM | 6.57 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 316.5 | nM | 6.50 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 384.36 | nM | 6.42 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 553.95 | nM | 6.26 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 783.6 | nM | 6.11 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 882.63 | nM | 6.05 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 888.18 | nM | 6.05 |
| CHEMBL64925 | MG-132 | IC50 | = | 938.54 | nM | 6.03 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 979.7 | nM | 6.01 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 1071.35 | nM | 5.97 |
| CHEMBL591429 | PAC-1 | IC50 | = | 1179.09 | nM | 5.93 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1257.05 | nM | 5.90 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1933.25 | nM | 5.71 |
| CHEMBL585951 | — | IC50 | = | 2029.53 | nM | 5.69 |
| CHEMBL803 | CYTARABINE | IC50 | = | 2578.16 | nM | 5.59 |
| CHEMBL2363137 | — | IC50 | = | 3150.12 | nM | 5.50 |
| CHEMBL191384 | — | IC50 | = | 3170.61 | nM | 5.50 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 3864.97 | nM | 5.41 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 3948.43 | nM | 5.40 |
| CHEMBL105442 | CI-1040 | IC50 | = | 5491.09 | nM | 5.26 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 5526.15 | nM | 5.26 |
| CHEMBL1190711 | — | IC50 | = | 5554.43 | nM | 5.25 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 5784.43 | nM | 5.24 |
| CHEMBL939 | GEFITINIB | IC50 | = | 5718.77 | nM | 5.24 |
| CHEMBL217354 | — | IC50 | = | 5891.44 | nM | 5.23 |
| CHEMBL221137 | EMBELIN | IC50 | = | 6802.89 | nM | 5.17 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 7607.43 | nM | 5.12 |
| CHEMBL1673039 | — | IC50 | = | 8558.88 | nM | 5.07 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 9136.81 | nM | 5.04 |