Assay Detail
Functional
CHEMBL2363269
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SANGER: Inhibition of human HCE-T cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCE-T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.54 | 9.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.79 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.36 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.39 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.35 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.26 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.91 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.70 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.68 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.54 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.44 |
| CHEMBL300389 | — | — | 1 | 7.33 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.31 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.08 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.96 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.90 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.88 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.78 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.78 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.75 |
| CHEMBL514499 | GW843682X | — | 1 | 6.66 |
| CHEMBL217354 | — | — | 1 | 6.64 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.55 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.43 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.43 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.41 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.36 |
| CHEMBL379300 | A-443654 | — | 1 | 6.35 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.14 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.06 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.1617 | nM | 9.79 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.4394 | nM | 9.36 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 4.068 | nM | 8.39 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 4.451 | nM | 8.35 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 5.469 | nM | 8.26 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 12.42 | nM | 7.91 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 20.01 | nM | 7.70 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 20.92 | nM | 7.68 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 28.6 | nM | 7.54 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 36.31 | nM | 7.44 |
| CHEMBL300389 | — | IC50 | = | 47.32 | nM | 7.33 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 49.17 | nM | 7.31 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 83.74 | nM | 7.08 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 109.4 | nM | 6.96 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 125.31 | nM | 6.90 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 132.05 | nM | 6.88 |
| CHEMBL513909 | BI-2536 | IC50 | = | 165.04 | nM | 6.78 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 164.87 | nM | 6.78 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 178.85 | nM | 6.75 |
| CHEMBL514499 | GW843682X | IC50 | = | 217.16 | nM | 6.66 |
| CHEMBL217354 | — | IC50 | = | 230.97 | nM | 6.64 |
| CHEMBL939 | GEFITINIB | IC50 | = | 279.79 | nM | 6.55 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 370.29 | nM | 6.43 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 371.53 | nM | 6.43 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 386.03 | nM | 6.41 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 441.87 | nM | 6.36 |
| CHEMBL379300 | A-443654 | IC50 | = | 450.8 | nM | 6.35 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 720.09 | nM | 6.14 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 875.84 | nM | 6.06 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 871.71 | nM | 6.06 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 884.28 | nM | 6.05 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 971.31 | nM | 6.01 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1088.19 | nM | 5.96 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1153.81 | nM | 5.94 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1179.83 | nM | 5.93 |
| CHEMBL473417 | VISMODEGIB | IC50 | = | 1322.47 | nM | 5.88 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 1567.14 | nM | 5.80 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1715.0 | nM | 5.77 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1934.51 | nM | 5.71 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 2087.94 | nM | 5.68 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 2205.98 | nM | 5.66 |
| CHEMBL64925 | MG-132 | IC50 | = | 2448.83 | nM | 5.61 |
| CHEMBL585951 | — | IC50 | = | 2790.74 | nM | 5.55 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 2787.96 | nM | 5.55 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2831.88 | nM | 5.55 |
| CHEMBL105442 | CI-1040 | IC50 | = | 2832.64 | nM | 5.55 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 3719.81 | nM | 5.43 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 4101.88 | nM | 5.39 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 4415.79 | nM | 5.36 |
| CHEMBL3349342 | — | IC50 | = | 6418.28 | nM | 5.19 |