Assay Detail
Functional
CHEMBL2363271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human HCT-15 cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.51 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.14 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.18 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.11 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.08 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 7.02 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.82 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.81 |
| CHEMBL217354 | — | — | 1 | 6.70 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.65 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.62 |
| CHEMBL585951 | — | — | 1 | 6.59 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.57 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.49 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.48 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.33 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.25 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.11 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 5.91 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.84 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 5.80 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.63 |
| CHEMBL259181 | — | — | 1 | 5.60 |
| CHEMBL135561 | — | — | 1 | 5.58 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.57 |
| CHEMBL558642 | GSK-650394 | — | 1 | 5.44 |
| CHEMBL1190711 | — | — | 1 | 5.18 |
| CHEMBL2363137 | — | — | 1 | 5.16 |
| CHEMBL399530 | — | — | 1 | 5.14 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.10 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.7166 | nM | 9.14 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 65.97 | nM | 7.18 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 78.58 | nM | 7.11 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 82.16 | nM | 7.08 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 95.1 | nM | 7.02 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 150.05 | nM | 6.82 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 154.75 | nM | 6.81 |
| CHEMBL217354 | — | IC50 | = | 201.56 | nM | 6.70 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 224.84 | nM | 6.65 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 237.14 | nM | 6.62 |
| CHEMBL585951 | — | IC50 | = | 258.19 | nM | 6.59 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 267.58 | nM | 6.57 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 327.05 | nM | 6.49 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 334.32 | nM | 6.48 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 464.62 | nM | 6.33 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 565.56 | nM | 6.25 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 776.97 | nM | 6.11 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1223.04 | nM | 5.91 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1430.68 | nM | 5.84 |
| CHEMBL591429 | PAC-1 | IC50 | = | 1583.0 | nM | 5.80 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2354.66 | nM | 5.63 |
| CHEMBL259181 | — | IC50 | = | 2494.51 | nM | 5.60 |
| CHEMBL135561 | — | IC50 | = | 2605.12 | nM | 5.58 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 2687.92 | nM | 5.57 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 3628.42 | nM | 5.44 |
| CHEMBL1190711 | — | IC50 | = | 6644.76 | nM | 5.18 |
| CHEMBL2363137 | — | IC50 | = | 6870.38 | nM | 5.16 |
| CHEMBL399530 | — | IC50 | = | 7236.26 | nM | 5.14 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 7870.59 | nM | 5.10 |
| CHEMBL803 | CYTARABINE | IC50 | = | 8123.11 | nM | 5.09 |
| CHEMBL221137 | EMBELIN | IC50 | = | 9245.99 | nM | 5.03 |
| CHEMBL258844 | — | IC50 | = | 10248.83 | nM | 4.99 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 13571.68 | nM | 4.87 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 14706.64 | nM | 4.83 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 14885.51 | nM | 4.83 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 15941.09 | nM | 4.80 |
| CHEMBL472004 | — | IC50 | = | 15874.77 | nM | 4.80 |
| CHEMBL1186585 | — | IC50 | = | 16992.07 | nM | 4.77 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 22744.06 | nM | 4.64 |
| CHEMBL191384 | — | IC50 | = | 23647.51 | nM | 4.63 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 25970.88 | nM | 4.59 |
| CHEMBL512504 | — | IC50 | = | 26938.94 | nM | 4.57 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 28419.2 | nM | 4.55 |
| CHEMBL939 | GEFITINIB | IC50 | = | 34127.04 | nM | 4.47 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 40590.74 | nM | 4.39 |
| CHEMBL472940 | — | IC50 | = | 58859.43 | nM | 4.23 |
| CHEMBL255342 | — | IC50 | = | 67284.17 | nM | 4.17 |
| CHEMBL176544 | — | IC50 | = | 74542.1 | nM | 4.13 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 82013.43 | nM | 4.09 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 85257.75 | nM | 4.07 |