Assay Detail
Functional
CHEMBL2363276
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SANGER: Inhibition of human HGC-27 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HGC-27 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.85 | 9.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.88 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.47 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.33 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.99 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.73 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.39 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 8.29 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 8.28 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.12 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.02 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.02 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.87 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.75 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.74 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.31 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.99 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.89 |
| CHEMBL217354 | — | — | 1 | 6.85 |
| CHEMBL258844 | — | — | 1 | 6.82 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.72 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.67 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.64 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.58 |
| CHEMBL585951 | — | — | 1 | 6.55 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.53 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.34 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.31 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 6.25 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 6.25 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.1307 | nM | 9.88 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.3383 | nM | 9.47 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.4709 | nM | 9.33 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.012 | nM | 8.99 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1.852 | nM | 8.73 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 4.073 | nM | 8.39 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 5.099 | nM | 8.29 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 5.245 | nM | 8.28 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 7.592 | nM | 8.12 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 9.601 | nM | 8.02 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 9.598 | nM | 8.02 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 13.56 | nM | 7.87 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 17.58 | nM | 7.75 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 18.06 | nM | 7.74 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 49.29 | nM | 7.31 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 102.12 | nM | 6.99 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 127.37 | nM | 6.89 |
| CHEMBL217354 | — | IC50 | = | 140.48 | nM | 6.85 |
| CHEMBL258844 | — | IC50 | = | 150.33 | nM | 6.82 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 189.63 | nM | 6.72 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 212.57 | nM | 6.67 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 228.34 | nM | 6.64 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 264.14 | nM | 6.58 |
| CHEMBL585951 | — | IC50 | = | 284.23 | nM | 6.55 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 293.53 | nM | 6.53 |
| CHEMBL803 | CYTARABINE | IC50 | = | 455.23 | nM | 6.34 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 491.15 | nM | 6.31 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 567.83 | nM | 6.25 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 564.99 | nM | 6.25 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 623.79 | nM | 6.21 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 872.34 | nM | 6.06 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1181.6 | nM | 5.93 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 1308.21 | nM | 5.88 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1317.64 | nM | 5.88 |
| CHEMBL259181 | — | IC50 | = | 2312.19 | nM | 5.64 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 2335.72 | nM | 5.63 |
| CHEMBL1190711 | — | IC50 | = | 2695.67 | nM | 5.57 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2836.36 | nM | 5.55 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 3229.9 | nM | 5.49 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 3798.74 | nM | 5.42 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 4095.49 | nM | 5.39 |
| CHEMBL2363137 | — | IC50 | = | 4028.19 | nM | 5.39 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 4296.6 | nM | 5.37 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 5376.82 | nM | 5.27 |
| CHEMBL393929 | — | IC50 | = | 5730.77 | nM | 5.24 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 6201.5 | nM | 5.21 |
| CHEMBL399530 | — | IC50 | = | 6129.26 | nM | 5.21 |
| CHEMBL191384 | — | IC50 | = | 6266.95 | nM | 5.20 |
| CHEMBL573107 | — | IC50 | = | 6357.86 | nM | 5.20 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 6652.7 | nM | 5.18 |