Assay Detail
Functional
CHEMBL2363278
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SANGER: Inhibition of human HL-60 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.87 | 8.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.45 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.43 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.36 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.33 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.30 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.02 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.95 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.80 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.74 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.61 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 7.61 |
| CHEMBL514499 | GW843682X | — | 1 | 7.60 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 7.54 |
| CHEMBL3349342 | — | — | 1 | 7.49 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.20 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.17 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.15 |
| CHEMBL512504 | — | — | 1 | 7.01 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.97 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.97 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.91 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.83 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.83 |
| CHEMBL2144069 | — | — | 1 | 6.81 |
| CHEMBL401930 | — | — | 1 | 6.54 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.54 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.51 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 6.47 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.39 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.585 | nM | 8.45 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 3.734 | nM | 8.43 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.371 | nM | 8.36 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 4.667 | nM | 8.33 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 5.002 | nM | 8.30 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 9.656 | nM | 8.02 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 11.15 | nM | 7.95 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 15.69 | nM | 7.80 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 18.07 | nM | 7.74 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 24.59 | nM | 7.61 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 24.78 | nM | 7.61 |
| CHEMBL514499 | GW843682X | IC50 | = | 25.21 | nM | 7.60 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 29.08 | nM | 7.54 |
| CHEMBL3349342 | — | IC50 | = | 32.4 | nM | 7.49 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 62.56 | nM | 7.20 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 66.77 | nM | 7.17 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 71.52 | nM | 7.15 |
| CHEMBL512504 | — | IC50 | = | 97.39 | nM | 7.01 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 106.36 | nM | 6.97 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 106.06 | nM | 6.97 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 123.1 | nM | 6.91 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 149.3 | nM | 6.83 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 149.2 | nM | 6.83 |
| CHEMBL2144069 | — | IC50 | = | 154.41 | nM | 6.81 |
| CHEMBL401930 | — | IC50 | = | 285.88 | nM | 6.54 |
| CHEMBL38 | TRETINOIN | IC50 | = | 284.91 | nM | 6.54 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 306.35 | nM | 6.51 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 340.66 | nM | 6.47 |
| CHEMBL105442 | CI-1040 | IC50 | = | 411.07 | nM | 6.39 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 425.75 | nM | 6.37 |
| CHEMBL509032 | TAE-684 | IC50 | = | 481.42 | nM | 6.32 |
| CHEMBL379300 | A-443654 | IC50 | = | 500.33 | nM | 6.30 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 542.61 | nM | 6.27 |
| CHEMBL585951 | — | IC50 | = | 545.56 | nM | 6.26 |
| CHEMBL300389 | — | IC50 | = | 562.84 | nM | 6.25 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 603.51 | nM | 6.22 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 773.55 | nM | 6.11 |
| CHEMBL573107 | — | IC50 | = | 883.62 | nM | 6.05 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1009.7 | nM | 6.00 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1013.05 | nM | 5.99 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 1065.74 | nM | 5.97 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1151.42 | nM | 5.94 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1255.88 | nM | 5.90 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 1269.59 | nM | 5.90 |
| CHEMBL188678 | — | IC50 | = | 1381.9 | nM | 5.86 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 1669.28 | nM | 5.78 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1923.05 | nM | 5.72 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1939.02 | nM | 5.71 |
| CHEMBL513909 | BI-2536 | IC50 | = | 1999.08 | nM | 5.70 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2291.81 | nM | 5.64 |