Assay Detail
Functional
CHEMBL2363280
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SANGER: Inhibition of human HMV-II cell growth in a cell viability assay.
90
Total Activities
89
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HMV-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 90 | 5.86 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.40 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 8.65 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.41 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.35 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.32 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.16 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.05 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.65 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.61 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.28 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.25 |
| CHEMBL9470 | SHIKONIN | — | 1 | 7.25 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 7.16 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 7.05 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.04 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.92 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.91 |
| CHEMBL585951 | — | — | 1 | 6.82 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.78 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.74 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.67 |
| CHEMBL217354 | — | — | 1 | 6.51 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.25 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.19 |
| CHEMBL1190711 | — | — | 1 | 6.18 |
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 6.13 |
| CHEMBL191384 | — | — | 1 | 6.10 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 5.88 |
| CHEMBL2363137 | — | — | 1 | 5.81 |
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.3944 | nM | 9.40 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 2.259 | nM | 8.65 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 3.905 | nM | 8.41 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 4.49 | nM | 8.35 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 4.768 | nM | 8.32 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 6.873 | nM | 8.16 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 8.887 | nM | 8.05 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 24.34 | nM | 7.61 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 52.39 | nM | 7.28 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 55.78 | nM | 7.25 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 56.4 | nM | 7.25 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 69.74 | nM | 7.16 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 88.46 | nM | 7.05 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 90.1 | nM | 7.04 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 120.2 | nM | 6.92 |
| CHEMBL803 | CYTARABINE | IC50 | = | 123.63 | nM | 6.91 |
| CHEMBL585951 | — | IC50 | = | 150.75 | nM | 6.82 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 166.06 | nM | 6.78 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 183.25 | nM | 6.74 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 215.78 | nM | 6.67 |
| CHEMBL217354 | — | IC50 | = | 309.31 | nM | 6.51 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 568.79 | nM | 6.25 |
| CHEMBL105442 | CI-1040 | IC50 | = | 644.65 | nM | 6.19 |
| CHEMBL1190711 | — | IC50 | = | 664.43 | nM | 6.18 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 748.74 | nM | 6.13 |
| CHEMBL191384 | — | IC50 | = | 793.3 | nM | 6.10 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 1301.92 | nM | 5.88 |
| CHEMBL2363137 | — | IC50 | = | 1542.83 | nM | 5.81 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 1704.88 | nM | 5.77 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1793.86 | nM | 5.75 |
| CHEMBL1090090 | VX-702 | IC50 | = | 1771.84 | nM | 5.75 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1878.58 | nM | 5.73 |
| CHEMBL573107 | — | IC50 | = | 2166.33 | nM | 5.66 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 2338.68 | nM | 5.63 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 2589.97 | nM | 5.59 |
| CHEMBL591429 | PAC-1 | IC50 | = | 2940.24 | nM | 5.53 |
| CHEMBL135561 | — | IC50 | = | 3003.42 | nM | 5.52 |
| CHEMBL221137 | EMBELIN | IC50 | = | 4611.44 | nM | 5.34 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4517.3 | nM | 5.34 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 5394.3 | nM | 5.27 |
| CHEMBL259181 | — | IC50 | = | 6340.52 | nM | 5.20 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 7511.96 | nM | 5.12 |
| CHEMBL102714 | SB-216763 | IC50 | = | 7676.07 | nM | 5.12 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 9340.65 | nM | 5.03 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 10017.18 | nM | 5.00 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 10511.33 | nM | 4.98 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 11161.17 | nM | 4.95 |
| CHEMBL379975 | — | IC50 | = | 12060.97 | nM | 4.92 |
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 14230.92 | nM | 4.85 |