Assay Detail
Functional
CHEMBL2363285
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SANGER: Inhibition of human HOS cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HOS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.73 | 10.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 10.32 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.67 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.11 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.86 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.85 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.71 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.60 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.49 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.20 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.68 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.46 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.43 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.34 |
| CHEMBL217354 | — | — | 1 | 7.07 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.97 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.84 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.73 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.63 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.38 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.34 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.32 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.30 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.29 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.25 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.24 |
| CHEMBL585951 | — | — | 1 | 6.21 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.14 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.06 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.89 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.04803 | nM | 10.32 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.2152 | nM | 9.67 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.7822 | nM | 9.11 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 1.378 | nM | 8.86 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1.398 | nM | 8.85 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1.957 | nM | 8.71 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 2.531 | nM | 8.60 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 3.218 | nM | 8.49 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 6.25 | nM | 8.20 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 21.06 | nM | 7.68 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 34.73 | nM | 7.46 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 36.88 | nM | 7.43 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 45.29 | nM | 7.34 |
| CHEMBL217354 | — | IC50 | = | 84.71 | nM | 7.07 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 106.7 | nM | 6.97 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 145.5 | nM | 6.84 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 186.08 | nM | 6.73 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 232.16 | nM | 6.63 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 416.82 | nM | 6.38 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 458.88 | nM | 6.34 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 473.76 | nM | 6.32 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 503.65 | nM | 6.30 |
| CHEMBL803 | CYTARABINE | IC50 | = | 518.22 | nM | 6.29 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 560.23 | nM | 6.25 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 571.92 | nM | 6.24 |
| CHEMBL585951 | — | IC50 | = | 613.49 | nM | 6.21 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 725.79 | nM | 6.14 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 879.95 | nM | 6.06 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1274.25 | nM | 5.89 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1352.96 | nM | 5.87 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 1495.58 | nM | 5.83 |
| CHEMBL577784 | BX-795 | IC50 | = | 1573.09 | nM | 5.80 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 1973.12 | nM | 5.71 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1979.48 | nM | 5.70 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2076.53 | nM | 5.68 |
| CHEMBL2363137 | — | IC50 | = | 2526.05 | nM | 5.60 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 2560.32 | nM | 5.59 |
| CHEMBL259181 | — | IC50 | = | 3076.7 | nM | 5.51 |
| CHEMBL591429 | PAC-1 | IC50 | = | 3343.18 | nM | 5.48 |
| CHEMBL1190711 | — | IC50 | = | 3323.81 | nM | 5.48 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 4096.32 | nM | 5.39 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 4291.41 | nM | 5.37 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 4385.67 | nM | 5.36 |
| CHEMBL573107 | — | IC50 | = | 4464.53 | nM | 5.35 |
| CHEMBL472940 | — | IC50 | = | 4497.43 | nM | 5.35 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 4697.7 | nM | 5.33 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 4802.82 | nM | 5.32 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 4786.3 | nM | 5.32 |
| CHEMBL105442 | CI-1040 | IC50 | = | 5629.23 | nM | 5.25 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 7036.86 | nM | 5.15 |