Assay Detail
Functional
CHEMBL2363289
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SANGER: Inhibition of human HSC-4 cell growth in a cell viability assay.
74
Total Activities
73
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HSC-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 74 | 5.95 | 9.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.99 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 9.95 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.74 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.62 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.63 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.32 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.76 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.52 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.21 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.12 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.98 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.77 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.76 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.69 |
| CHEMBL217354 | — | — | 1 | 6.67 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.61 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.39 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.36 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.33 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.20 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.18 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.07 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.06 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.90 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.80 |
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 5.71 |
| CHEMBL176544 | — | — | 1 | 5.71 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.67 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.55 |
| CHEMBL585951 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.1022 | nM | 9.99 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 0.1134 | nM | 9.95 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.1816 | nM | 9.74 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.2385 | nM | 9.62 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 2.355 | nM | 8.63 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 4.803 | nM | 8.32 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 17.48 | nM | 7.76 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 29.92 | nM | 7.52 |
| CHEMBL939 | GEFITINIB | IC50 | = | 61.53 | nM | 7.21 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 75.76 | nM | 7.12 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 105.54 | nM | 6.98 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 171.58 | nM | 6.77 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 171.6 | nM | 6.76 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 202.92 | nM | 6.69 |
| CHEMBL217354 | — | IC50 | = | 213.23 | nM | 6.67 |
| CHEMBL105442 | CI-1040 | IC50 | = | 243.95 | nM | 6.61 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 403.46 | nM | 6.39 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 434.45 | nM | 6.36 |
| CHEMBL803 | CYTARABINE | IC50 | = | 467.41 | nM | 6.33 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 627.25 | nM | 6.20 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 666.98 | nM | 6.18 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 846.51 | nM | 6.07 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 862.7 | nM | 6.06 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1262.52 | nM | 5.90 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 1581.34 | nM | 5.80 |
| CHEMBL176544 | — | IC50 | = | 1945.2 | nM | 5.71 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 1938.39 | nM | 5.71 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 2118.83 | nM | 5.67 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 2783.89 | nM | 5.55 |
| CHEMBL585951 | — | IC50 | = | 4253.84 | nM | 5.37 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 4403.37 | nM | 5.36 |
| CHEMBL399530 | — | IC50 | = | 5115.38 | nM | 5.29 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 6472.78 | nM | 5.19 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 8212.98 | nM | 5.08 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 8287.2 | nM | 5.08 |
| CHEMBL1190711 | — | IC50 | = | 10218.97 | nM | 4.99 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 10739.76 | nM | 4.97 |
| CHEMBL221137 | EMBELIN | IC50 | = | 11117.4 | nM | 4.95 |
| CHEMBL255342 | — | IC50 | = | 11670.33 | nM | 4.93 |
| CHEMBL2363137 | — | IC50 | = | 12201.57 | nM | 4.91 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 17660.14 | nM | 4.75 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 18534.28 | nM | 4.73 |
| CHEMBL258844 | — | IC50 | = | 23730.64 | nM | 4.62 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 28730.58 | nM | 4.54 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 35596.49 | nM | 4.45 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 36421.13 | nM | 4.44 |
| CHEMBL38 | TRETINOIN | IC50 | = | 44550.62 | nM | 4.35 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 51114.49 | nM | 4.29 |
| CHEMBL1090090 | VX-702 | IC50 | = | 63856.35 | nM | 4.20 |
| CHEMBL135561 | — | IC50 | = | 65621.8 | nM | 4.18 |