Assay Detail
Functional
CHEMBL2363290
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SANGER: Inhibition of human HT cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.61 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.52 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.24 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.81 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.75 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.69 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.67 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.56 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.53 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.40 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.39 |
| CHEMBL300389 | — | — | 1 | 7.18 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.10 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.09 |
| CHEMBL514499 | GW843682X | — | 1 | 6.89 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.87 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.87 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.65 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.59 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.53 |
| CHEMBL512504 | — | — | 1 | 6.47 |
| CHEMBL379300 | A-443654 | — | 1 | 6.43 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.39 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.33 |
| CHEMBL585951 | — | — | 1 | 6.20 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 6.20 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.02 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.96 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.95 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.95 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 3.025 | nM | 8.52 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 15.64 | nM | 7.81 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 20.47 | nM | 7.69 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 21.58 | nM | 7.67 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 27.56 | nM | 7.56 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 29.71 | nM | 7.53 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 40.07 | nM | 7.40 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 41.02 | nM | 7.39 |
| CHEMBL300389 | — | IC50 | = | 66.16 | nM | 7.18 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 80.86 | nM | 7.09 |
| CHEMBL514499 | GW843682X | IC50 | = | 128.41 | nM | 6.89 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 133.69 | nM | 6.87 |
| CHEMBL513909 | BI-2536 | IC50 | = | 135.74 | nM | 6.87 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 225.66 | nM | 6.65 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 256.21 | nM | 6.59 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 293.8 | nM | 6.53 |
| CHEMBL512504 | — | IC50 | = | 334.82 | nM | 6.47 |
| CHEMBL379300 | A-443654 | IC50 | = | 373.34 | nM | 6.43 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 405.15 | nM | 6.39 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 465.81 | nM | 6.33 |
| CHEMBL585951 | — | IC50 | = | 633.44 | nM | 6.20 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 632.39 | nM | 6.20 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 960.58 | nM | 6.02 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1087.45 | nM | 5.96 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1134.78 | nM | 5.95 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1133.96 | nM | 5.95 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1536.59 | nM | 5.81 |
| CHEMBL64925 | MG-132 | IC50 | = | 1700.43 | nM | 5.77 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1873.42 | nM | 5.73 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1889.47 | nM | 5.72 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 2104.54 | nM | 5.68 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 2687.54 | nM | 5.57 |
| CHEMBL2363137 | — | IC50 | = | 2745.88 | nM | 5.56 |
| CHEMBL379975 | — | IC50 | = | 2968.84 | nM | 5.53 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 4022.96 | nM | 5.39 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 4443.21 | nM | 5.35 |
| CHEMBL221137 | EMBELIN | IC50 | = | 5512.58 | nM | 5.26 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 5555.05 | nM | 5.25 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 5931.53 | nM | 5.23 |
| CHEMBL1190711 | — | IC50 | = | 6223.63 | nM | 5.21 |
| CHEMBL591429 | PAC-1 | IC50 | = | 6805.14 | nM | 5.17 |
| CHEMBL188678 | — | IC50 | = | 8364.9 | nM | 5.08 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 8290.45 | nM | 5.08 |
| CHEMBL1673039 | — | IC50 | = | 8769.13 | nM | 5.06 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 8941.85 | nM | 5.05 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 9940.18 | nM | 5.00 |
| CHEMBL105442 | CI-1040 | IC50 | = | 12834.57 | nM | 4.89 |