Assay Detail
Functional
CHEMBL2363291
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SANGER: Inhibition of human HT-1080 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.99 | 9.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.95 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.40 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.30 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.07 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.60 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.37 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.30 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.23 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.83 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.75 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.66 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.66 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.39 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.13 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.07 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.07 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.96 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.94 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.80 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.63 |
| CHEMBL217354 | — | — | 1 | 6.59 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.58 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.45 |
| CHEMBL585951 | — | — | 1 | 6.37 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.31 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.29 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.28 |
| CHEMBL3349342 | — | — | 1 | 6.27 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.26 |
| CHEMBL2363137 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.112 | nM | 9.95 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.3944 | nM | 9.40 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.5011 | nM | 9.30 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.8424 | nM | 9.07 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 2.495 | nM | 8.60 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.228 | nM | 8.37 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 4.993 | nM | 8.30 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 5.834 | nM | 8.23 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 14.82 | nM | 7.83 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 17.93 | nM | 7.75 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 22.14 | nM | 7.66 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 21.93 | nM | 7.66 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 40.31 | nM | 7.39 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 73.87 | nM | 7.13 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 85.88 | nM | 7.07 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 84.39 | nM | 7.07 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 108.53 | nM | 6.96 |
| CHEMBL803 | CYTARABINE | IC50 | = | 114.47 | nM | 6.94 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 159.82 | nM | 6.80 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 233.57 | nM | 6.63 |
| CHEMBL217354 | — | IC50 | = | 255.53 | nM | 6.59 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 259.95 | nM | 6.58 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 353.71 | nM | 6.45 |
| CHEMBL585951 | — | IC50 | = | 427.7 | nM | 6.37 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 492.7 | nM | 6.31 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 511.19 | nM | 6.29 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 525.43 | nM | 6.28 |
| CHEMBL3349342 | — | IC50 | = | 538.3 | nM | 6.27 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 553.49 | nM | 6.26 |
| CHEMBL2363137 | — | IC50 | = | 675.35 | nM | 6.17 |
| CHEMBL379975 | — | IC50 | = | 1197.68 | nM | 5.92 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1375.19 | nM | 5.86 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 2430.1 | nM | 5.61 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2448.64 | nM | 5.61 |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 2487.64 | nM | 5.60 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2768.38 | nM | 5.56 |
| CHEMBL399530 | — | IC50 | = | 2816.28 | nM | 5.55 |
| CHEMBL105442 | CI-1040 | IC50 | = | 3019.97 | nM | 5.52 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 3086.06 | nM | 5.51 |
| CHEMBL1190711 | — | IC50 | = | 3225.05 | nM | 5.49 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 3917.75 | nM | 5.41 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 4199.21 | nM | 5.38 |
| CHEMBL221137 | EMBELIN | IC50 | = | 4759.95 | nM | 5.32 |
| CHEMBL259181 | — | IC50 | = | 5127.97 | nM | 5.29 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 5493.47 | nM | 5.26 |
| CHEMBL135561 | — | IC50 | = | 5978.59 | nM | 5.22 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 6109.46 | nM | 5.21 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 6496.83 | nM | 5.19 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 6411.79 | nM | 5.19 |
| CHEMBL573107 | — | IC50 | = | 6540.42 | nM | 5.18 |