Assay Detail
Functional
CHEMBL2363294
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SANGER: Inhibition of human HT-144 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-144 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.91 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.80 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.29 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.24 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 9.23 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.81 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.76 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.48 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.46 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 8.37 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.31 |
| CHEMBL2144069 | — | — | 1 | 8.18 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.10 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 8.05 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.88 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.84 |
| CHEMBL514499 | GW843682X | — | 1 | 7.79 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.75 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.70 |
| CHEMBL300389 | — | — | 1 | 7.69 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.62 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.51 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.42 |
| CHEMBL3349342 | — | — | 1 | 7.31 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 7.26 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.21 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 7.05 |
| CHEMBL64925 | MG-132 | — | 2 | 6.86 |
| CHEMBL585951 | — | — | 1 | 6.83 |
| CHEMBL379300 | A-443654 | — | 1 | 6.82 |
| CHEMBL217354 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.1574 | nM | 9.80 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.5183 | nM | 9.29 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.5759 | nM | 9.24 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 0.5909 | nM | 9.23 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 1.546 | nM | 8.81 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.72 | nM | 8.76 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 3.319 | nM | 8.48 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 3.509 | nM | 8.46 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 4.296 | nM | 8.37 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 4.92 | nM | 8.31 |
| CHEMBL2144069 | — | IC50 | = | 6.606 | nM | 8.18 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 8.003 | nM | 8.10 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 8.974 | nM | 8.05 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 13.03 | nM | 7.88 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 14.51 | nM | 7.84 |
| CHEMBL514499 | GW843682X | IC50 | = | 16.35 | nM | 7.79 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 17.86 | nM | 7.75 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 20.09 | nM | 7.70 |
| CHEMBL300389 | — | IC50 | = | 20.59 | nM | 7.69 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 23.75 | nM | 7.62 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 30.93 | nM | 7.51 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 37.91 | nM | 7.42 |
| CHEMBL3349342 | — | IC50 | = | 48.97 | nM | 7.31 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 55.14 | nM | 7.26 |
| CHEMBL513909 | BI-2536 | IC50 | = | 61.3 | nM | 7.21 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 89.05 | nM | 7.05 |
| CHEMBL64925 | MG-132 | IC50 | = | 138.95 | nM | 6.86 |
| CHEMBL585951 | — | IC50 | = | 146.59 | nM | 6.83 |
| CHEMBL217354 | — | IC50 | = | 152.01 | nM | 6.82 |
| CHEMBL379300 | A-443654 | IC50 | = | 152.59 | nM | 6.82 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 165.43 | nM | 6.78 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 196.15 | nM | 6.71 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 261.91 | nM | 6.58 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 302.56 | nM | 6.52 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 300.14 | nM | 6.52 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 309.7 | nM | 6.51 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 312.8 | nM | 6.50 |
| CHEMBL64925 | MG-132 | IC50 | = | 334.22 | nM | 6.48 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 338.1 | nM | 6.47 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 363.29 | nM | 6.44 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 389.48 | nM | 6.41 |
| CHEMBL477989 | SB590885 | IC50 | = | 434.76 | nM | 6.36 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 536.09 | nM | 6.27 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 561.17 | nM | 6.25 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 637.98 | nM | 6.20 |
| CHEMBL105442 | CI-1040 | IC50 | = | 646.57 | nM | 6.19 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 977.74 | nM | 6.01 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1170.7 | nM | 5.93 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1231.01 | nM | 5.91 |
| CHEMBL213100 | — | IC50 | = | 1445.17 | nM | 5.84 |