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Assay Detail

CHEMBL2363296

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
SANGER: Inhibition of human HT-3 cell growth in a cell viability assay.
ChEMBL ↗
98
Total Activities
97
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-3
Confidence 1 — Organism
Curated By Autocuration

Target

HT-3 (CHEMBL1075470) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 98 5.54 9.67

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL65 CAMPTOTHECIN -1.0 1 9.67
CHEMBL3545252 DOCETAXEL 4.0 1 8.55
CHEMBL105 MITOMYCIN 4.0 1 8.53
CHEMBL94657 PATUPILONE 3.0 1 7.83
CHEMBL96926 THAPSIGARGIN — 1 7.66
CHEMBL159 VINBLASTINE 4.0 1 7.43
CHEMBL34259 METHOTREXATE 4.0 1 7.16
CHEMBL585951 — — 1 6.99
CHEMBL553025 VINORELBINE 4.0 1 6.89
CHEMBL53463 DOXORUBICIN 4.0 1 6.88
CHEMBL217354 — — 1 6.72
CHEMBL888 GEMCITABINE 4.0 1 6.70
CHEMBL1972860 ELESCLOMOL 3.0 1 6.67
CHEMBL1201182 TEMSIROLIMUS 4.0 1 6.50
CHEMBL1879463 DACTOLISIB 3.0 1 6.42
CHEMBL603469 LESTAURTINIB 3.0 1 6.35
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.33
CHEMBL109480 TANESPIMYCIN 3.0 1 6.32
CHEMBL2041933 AZD-7762 1.0 1 6.31
CHEMBL507361 MIRDAMETINIB 2.0 1 6.29
CHEMBL409 BICALUTAMIDE 4.0 1 6.14
CHEMBL252164 LUMINESPIB 2.0 1 6.05
CHEMBL9470 SHIKONIN — 1 6.02
CHEMBL939 GEFITINIB 4.0 1 6.01
CHEMBL44657 ETOPOSIDE 4.0 1 5.95
CHEMBL1173655 AFATINIB 4.0 1 5.89
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 5.88
CHEMBL803 CYTARABINE 4.0 1 5.86
CHEMBL1801204 AZD-8055 1.0 1 5.78
CHEMBL573107 — — 1 5.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL65 CAMPTOTHECIN IC50 = 0.2119 nM 9.67
CHEMBL3545252 DOCETAXEL IC50 = 2.818 nM 8.55
CHEMBL105 MITOMYCIN IC50 = 2.928 nM 8.53
CHEMBL94657 PATUPILONE IC50 = 14.97 nM 7.83
CHEMBL96926 THAPSIGARGIN IC50 = 21.72 nM 7.66
CHEMBL159 VINBLASTINE IC50 = 37.07 nM 7.43
CHEMBL34259 METHOTREXATE IC50 = 69.37 nM 7.16
CHEMBL585951 — IC50 = 101.92 nM 6.99
CHEMBL553025 VINORELBINE IC50 = 128.29 nM 6.89
CHEMBL53463 DOXORUBICIN IC50 = 133.04 nM 6.88
CHEMBL217354 — IC50 = 192.06 nM 6.72
CHEMBL888 GEMCITABINE IC50 = 200.54 nM 6.70
CHEMBL1972860 ELESCLOMOL IC50 = 211.64 nM 6.67
CHEMBL1201182 TEMSIROLIMUS IC50 = 315.93 nM 6.50
CHEMBL1879463 DACTOLISIB IC50 = 379.95 nM 6.42
CHEMBL603469 LESTAURTINIB IC50 = 449.17 nM 6.35
CHEMBL449158 BRYOSTATIN 1 IC50 = 467.04 nM 6.33
CHEMBL109480 TANESPIMYCIN IC50 = 482.17 nM 6.32
CHEMBL2041933 AZD-7762 IC50 = 490.3 nM 6.31
CHEMBL507361 MIRDAMETINIB IC50 = 507.5 nM 6.29
CHEMBL409 BICALUTAMIDE IC50 = 731.34 nM 6.14
CHEMBL252164 LUMINESPIB IC50 = 894.2 nM 6.05
CHEMBL9470 SHIKONIN IC50 = 948.27 nM 6.02
CHEMBL939 GEFITINIB IC50 = 982.41 nM 6.01
CHEMBL44657 ETOPOSIDE IC50 = 1128.47 nM 5.95
CHEMBL1173655 AFATINIB IC50 = 1287.53 nM 5.89
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 1305.29 nM 5.88
CHEMBL803 CYTARABINE IC50 = 1381.52 nM 5.86
CHEMBL1801204 AZD-8055 IC50 = 1656.6 nM 5.78
CHEMBL573107 — IC50 = 2510.24 nM 5.60
CHEMBL521851 PICTILISIB IC50 = 2492.59 nM 5.60
CHEMBL98 VORINOSTAT IC50 = 2495.35 nM 5.60
CHEMBL575448 BMS-754807 IC50 = 3668.57 nM 5.44
CHEMBL11359 CISPLATIN IC50 = 5039.61 nM 5.30
CHEMBL577784 BX-795 IC50 = 5572.36 nM 5.25
CHEMBL6067492 BLEOMYCIN IC50 = 5777.14 nM 5.24
CHEMBL3349342 — IC50 = 6023.59 nM 5.22
CHEMBL608533 MIDOSTAURIN IC50 = 7102.61 nM 5.15
CHEMBL1084546 PF-00562271 IC50 = 7034.9 nM 5.15
CHEMBL379975 — IC50 = 8507.86 nM 5.07
CHEMBL512504 — IC50 = 9475.4 nM 5.02
CHEMBL412142 LADUVIGLUSIB IC50 = 10617.87 nM 4.97
CHEMBL176544 — IC50 = 11058.96 nM 4.96
CHEMBL443684 NAVITOCLAX IC50 = 17591.36 nM 4.75
CHEMBL105442 CI-1040 IC50 = 18397.72 nM 4.74
CHEMBL1091644 LINSITINIB IC50 = 18983.04 nM 4.72
CHEMBL393929 — IC50 = 20028.03 nM 4.70
CHEMBL2137530 SERDEMETAN IC50 = 21370.68 nM 4.67
CHEMBL1079175 MK-2206 IC50 = 21563.09 nM 4.67
CHEMBL135561 — IC50 = 23716.17 nM 4.62