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Assay Detail

CHEMBL2363299

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Functional
SANGER: Inhibition of human HUTU-80 cell growth in a cell viability assay.
ChEMBL ↗
118
Total Activities
116
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HUTU-80
Confidence 1 — Organism
Curated By Autocuration

Target

HuTu80 (CHEMBL614582) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 118 6.03 10.78

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL888 GEMCITABINE 4.0 1 10.78
CHEMBL6067492 BLEOMYCIN 4.0 1 9.87
CHEMBL94657 PATUPILONE 3.0 1 9.48
CHEMBL325041 BORTEZOMIB 3.0 1 9.27
CHEMBL96926 THAPSIGARGIN — 1 9.18
CHEMBL1972860 ELESCLOMOL 3.0 1 9.10
CHEMBL428647 PACLITAXEL 4.0 1 8.77
CHEMBL53463 DOXORUBICIN 4.0 1 8.67
CHEMBL553025 VINORELBINE 4.0 1 8.66
CHEMBL65 CAMPTOTHECIN -1.0 1 8.47
CHEMBL413 SIROLIMUS 4.0 1 8.35
CHEMBL105 MITOMYCIN 4.0 1 8.32
CHEMBL1256459 TORIN1 — 1 8.03
CHEMBL159 VINBLASTINE 4.0 1 7.91
CHEMBL252164 LUMINESPIB 2.0 1 7.70
CHEMBL300389 — — 1 7.69
CHEMBL514499 GW843682X — 1 7.65
CHEMBL513909 BI-2536 2.0 1 7.58
CHEMBL572878 TOZASERTIB 2.0 1 7.28
CHEMBL449158 BRYOSTATIN 1 2.0 1 7.13
CHEMBL217354 — — 1 7.06
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.98
CHEMBL379300 A-443654 — 1 6.94
CHEMBL213100 — — 1 6.76
CHEMBL608533 MIDOSTAURIN 4.0 1 6.76
CHEMBL44657 ETOPOSIDE 4.0 1 6.66
CHEMBL575448 BMS-754807 2.0 1 6.55
CHEMBL289228 TIPIFARNIB 3.0 1 6.54
CHEMBL5416410 DASATINIB 4.0 1 6.50
CHEMBL9470 SHIKONIN — 1 6.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL888 GEMCITABINE IC50 = 0.01664 nM 10.78
CHEMBL6067492 BLEOMYCIN IC50 = 0.1358 nM 9.87
CHEMBL94657 PATUPILONE IC50 = 0.3281 nM 9.48
CHEMBL325041 BORTEZOMIB IC50 = 0.533 nM 9.27
CHEMBL96926 THAPSIGARGIN IC50 = 0.6572 nM 9.18
CHEMBL1972860 ELESCLOMOL IC50 = 0.7911 nM 9.10
CHEMBL428647 PACLITAXEL IC50 = 1.682 nM 8.77
CHEMBL53463 DOXORUBICIN IC50 = 2.118 nM 8.67
CHEMBL553025 VINORELBINE IC50 = 2.177 nM 8.66
CHEMBL65 CAMPTOTHECIN IC50 = 3.382 nM 8.47
CHEMBL413 SIROLIMUS IC50 = 4.425 nM 8.35
CHEMBL105 MITOMYCIN IC50 = 4.83 nM 8.32
CHEMBL1256459 TORIN1 IC50 = 9.29 nM 8.03
CHEMBL159 VINBLASTINE IC50 = 12.28 nM 7.91
CHEMBL252164 LUMINESPIB IC50 = 20.04 nM 7.70
CHEMBL300389 — IC50 = 20.23 nM 7.69
CHEMBL514499 GW843682X IC50 = 22.33 nM 7.65
CHEMBL513909 BI-2536 IC50 = 26.24 nM 7.58
CHEMBL572878 TOZASERTIB IC50 = 52.99 nM 7.28
CHEMBL449158 BRYOSTATIN 1 IC50 = 74.86 nM 7.13
CHEMBL217354 — IC50 = 87.01 nM 7.06
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 103.65 nM 6.98
CHEMBL379300 A-443654 IC50 = 113.71 nM 6.94
CHEMBL213100 — IC50 = 175.29 nM 6.76
CHEMBL608533 MIDOSTAURIN IC50 = 172.79 nM 6.76
CHEMBL44657 ETOPOSIDE IC50 = 216.76 nM 6.66
CHEMBL575448 BMS-754807 IC50 = 278.84 nM 6.55
CHEMBL289228 TIPIFARNIB IC50 = 285.02 nM 6.54
CHEMBL5416410 DASATINIB IC50 = 314.2 nM 6.50
CHEMBL9470 SHIKONIN IC50 = 370.2 nM 6.43
CHEMBL401930 — IC50 = 466.11 nM 6.33
CHEMBL509032 TAE-684 IC50 = 473.75 nM 6.32
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 546.47 nM 6.26
CHEMBL803 CYTARABINE IC50 = 561.22 nM 6.25
CHEMBL603469 LESTAURTINIB IC50 = 648.59 nM 6.19
CHEMBL1171837 PONATINIB IC50 = 733.49 nM 6.13
CHEMBL2144069 — IC50 = 983.31 nM 6.01
CHEMBL2363137 — IC50 = 1149.69 nM 5.94
CHEMBL477772 PAZOPANIB IC50 = 1281.03 nM 5.89
CHEMBL558642 GSK-650394 IC50 = 1301.72 nM 5.88
CHEMBL259181 — IC50 = 1306.59 nM 5.88
CHEMBL1084546 PF-00562271 IC50 = 1448.86 nM 5.84
CHEMBL197603 — IC50 = 1504.79 nM 5.82
CHEMBL27759 ENTINOSTAT IC50 = 1795.08 nM 5.75
CHEMBL1190711 — IC50 = 1811.56 nM 5.74
CHEMBL221137 EMBELIN IC50 = 2354.41 nM 5.63
CHEMBL573107 — IC50 = 3666.21 nM 5.44
CHEMBL220241 GSK-269962A IC50 = 3789.86 nM 5.42
CHEMBL585951 — IC50 = 4230.97 nM 5.37
CHEMBL2041933 AZD-7762 IC50 = 5753.33 nM 5.24