Assay Detail
Functional
CHEMBL2363302
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SANGER: Inhibition of human HuH-7 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.58 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.62 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.15 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.92 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.91 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.87 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.75 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.74 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.53 |
| CHEMBL217354 | — | — | 1 | 7.48 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.15 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.06 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.94 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.59 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.56 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.42 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.36 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.25 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.14 |
| CHEMBL585951 | — | — | 1 | 6.12 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.92 |
| CHEMBL189584 | PD-173074 | — | 1 | 5.91 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.86 |
| CHEMBL3349342 | — | — | 1 | 5.83 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 5.80 |
| CHEMBL2363137 | — | — | 1 | 5.80 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 5.78 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.71 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.64 |
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 5.62 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.2396 | nM | 9.62 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 7.111 | nM | 8.15 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 12.32 | nM | 7.91 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 13.54 | nM | 7.87 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 17.64 | nM | 7.75 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 29.57 | nM | 7.53 |
| CHEMBL217354 | — | IC50 | = | 32.82 | nM | 7.48 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 70.35 | nM | 7.15 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 87.74 | nM | 7.06 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 115.84 | nM | 6.94 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 258.44 | nM | 6.59 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 277.63 | nM | 6.56 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 379.1 | nM | 6.42 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 433.72 | nM | 6.36 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 568.61 | nM | 6.25 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 720.41 | nM | 6.14 |
| CHEMBL585951 | — | IC50 | = | 755.67 | nM | 6.12 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1209.49 | nM | 5.92 |
| CHEMBL189584 | PD-173074 | IC50 | = | 1244.64 | nM | 5.91 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1395.01 | nM | 5.86 |
| CHEMBL3349342 | — | IC50 | = | 1472.59 | nM | 5.83 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 1600.98 | nM | 5.80 |
| CHEMBL2363137 | — | IC50 | = | 1571.16 | nM | 5.80 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 1672.93 | nM | 5.78 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1955.26 | nM | 5.71 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2306.37 | nM | 5.64 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 2421.65 | nM | 5.62 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2434.56 | nM | 5.61 |
| CHEMBL188678 | — | IC50 | = | 2567.02 | nM | 5.59 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2563.77 | nM | 5.59 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 2789.23 | nM | 5.55 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 3094.64 | nM | 5.51 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 3188.89 | nM | 5.50 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 3222.86 | nM | 5.49 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 3584.14 | nM | 5.45 |
| CHEMBL477989 | SB590885 | IC50 | = | 3670.16 | nM | 5.43 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 4496.57 | nM | 5.35 |
| CHEMBL577784 | BX-795 | IC50 | = | 4822.22 | nM | 5.32 |
| CHEMBL105442 | CI-1040 | IC50 | = | 5271.47 | nM | 5.28 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 5335.24 | nM | 5.27 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 6050.76 | nM | 5.22 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 6120.95 | nM | 5.21 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 7693.84 | nM | 5.11 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 8152.79 | nM | 5.09 |
| CHEMBL573107 | — | IC50 | = | 8730.12 | nM | 5.06 |
| CHEMBL258844 | — | IC50 | = | 8674.9 | nM | 5.06 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 9665.66 | nM | 5.01 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 10570.53 | nM | 4.98 |