Assay Detail
Functional
CHEMBL2363307
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SANGER: Inhibition of human IA-LM cell growth in a cell viability assay.
124
Total Activities
123
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IA-LM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 124 | 5.70 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.41 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.62 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.55 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.43 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.23 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.96 |
| CHEMBL514499 | GW843682X | — | 1 | 7.95 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.92 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.88 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.77 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.54 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 7.32 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.22 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.20 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.17 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.16 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.13 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.07 |
| CHEMBL300389 | — | — | 1 | 7.03 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.97 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.96 |
| CHEMBL379300 | A-443654 | — | 1 | 6.70 |
| CHEMBL585951 | — | — | 1 | 6.43 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.24 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.22 |
| CHEMBL135561 | — | — | 1 | 6.02 |
| CHEMBL64925 | MG-132 | — | 1 | 5.91 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.86 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.85 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.3929 | nM | 9.41 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 2.386 | nM | 8.62 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.802 | nM | 8.55 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 3.713 | nM | 8.43 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 5.906 | nM | 8.23 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 10.86 | nM | 7.96 |
| CHEMBL514499 | GW843682X | IC50 | = | 11.19 | nM | 7.95 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL513909 | BI-2536 | IC50 | = | 16.88 | nM | 7.77 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 29.17 | nM | 7.54 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 47.52 | nM | 7.32 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 60.53 | nM | 7.22 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 63.54 | nM | 7.20 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 68.13 | nM | 7.17 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 68.58 | nM | 7.16 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 73.28 | nM | 7.13 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 84.43 | nM | 7.07 |
| CHEMBL300389 | — | IC50 | = | 93.19 | nM | 7.03 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 107.51 | nM | 6.97 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 108.63 | nM | 6.96 |
| CHEMBL379300 | A-443654 | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL585951 | — | IC50 | = | 371.33 | nM | 6.43 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 570.86 | nM | 6.24 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 596.09 | nM | 6.22 |
| CHEMBL135561 | — | IC50 | = | 955.02 | nM | 6.02 |
| CHEMBL64925 | MG-132 | IC50 | = | 1241.16 | nM | 5.91 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1390.79 | nM | 5.86 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1399.86 | nM | 5.85 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1409.14 | nM | 5.85 |
| CHEMBL217354 | — | IC50 | = | 1557.81 | nM | 5.81 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1692.78 | nM | 5.77 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 1897.34 | nM | 5.72 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 2080.5 | nM | 5.68 |
| CHEMBL221137 | EMBELIN | IC50 | = | 2226.52 | nM | 5.65 |
| CHEMBL1190711 | — | IC50 | = | 2711.58 | nM | 5.57 |
| CHEMBL191384 | — | IC50 | = | 2731.42 | nM | 5.56 |
| CHEMBL258844 | — | IC50 | = | 3088.34 | nM | 5.51 |
| CHEMBL2363137 | — | IC50 | = | 3054.82 | nM | 5.51 |
| CHEMBL515416 | — | IC50 | = | 3213.7 | nM | 5.49 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 3401.7 | nM | 5.47 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3435.69 | nM | 5.46 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 3840.92 | nM | 5.42 |
| CHEMBL3349342 | — | IC50 | = | 4191.36 | nM | 5.38 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 4117.17 | nM | 5.38 |
| CHEMBL188678 | — | IC50 | = | 4279.35 | nM | 5.37 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 4706.35 | nM | 5.33 |
| CHEMBL577784 | BX-795 | IC50 | = | 4853.73 | nM | 5.31 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 4994.35 | nM | 5.30 |
| CHEMBL209148 | — | IC50 | = | 5389.62 | nM | 5.27 |