Assay Detail
Functional
CHEMBL2363316
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SANGER: Inhibition of human IST-SL2 cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IST-SL2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.85 | 10.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 10.23 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 9.76 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.88 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.17 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.15 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.77 |
| CHEMBL300389 | — | — | 1 | 7.60 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.37 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.27 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.24 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.16 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.13 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.02 |
| CHEMBL514499 | GW843682X | — | 1 | 6.95 |
| CHEMBL379300 | A-443654 | — | 1 | 6.71 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.70 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.68 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.41 |
| CHEMBL585951 | — | — | 1 | 6.34 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.30 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.20 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.14 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.10 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.07 |
| CHEMBL1190711 | — | — | 1 | 5.97 |
| CHEMBL197603 | — | — | 1 | 5.93 |
| CHEMBL213100 | — | — | 1 | 5.83 |
| CHEMBL64925 | MG-132 | — | 2 | 5.70 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.70 |
| CHEMBL509032 | TAE-684 | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.05844 | nM | 10.23 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 0.1732 | nM | 9.76 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 1.309 | nM | 8.88 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 6.764 | nM | 8.17 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 7.032 | nM | 8.15 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 17.14 | nM | 7.77 |
| CHEMBL300389 | — | IC50 | = | 24.88 | nM | 7.60 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 42.75 | nM | 7.37 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 53.62 | nM | 7.27 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 57.43 | nM | 7.24 |
| CHEMBL513909 | BI-2536 | IC50 | = | 70.04 | nM | 7.16 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 73.81 | nM | 7.13 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 94.68 | nM | 7.02 |
| CHEMBL514499 | GW843682X | IC50 | = | 112.06 | nM | 6.95 |
| CHEMBL379300 | A-443654 | IC50 | = | 193.69 | nM | 6.71 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 200.14 | nM | 6.70 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 208.63 | nM | 6.68 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 387.62 | nM | 6.41 |
| CHEMBL585951 | — | IC50 | = | 456.82 | nM | 6.34 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 503.02 | nM | 6.30 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 625.22 | nM | 6.20 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 719.82 | nM | 6.14 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 791.28 | nM | 6.10 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 850.03 | nM | 6.07 |
| CHEMBL1190711 | — | IC50 | = | 1071.17 | nM | 5.97 |
| CHEMBL197603 | — | IC50 | = | 1161.81 | nM | 5.93 |
| CHEMBL213100 | — | IC50 | = | 1474.21 | nM | 5.83 |
| CHEMBL64925 | MG-132 | IC50 | = | 2012.52 | nM | 5.70 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 2002.62 | nM | 5.70 |
| CHEMBL509032 | TAE-684 | IC50 | = | 2124.45 | nM | 5.67 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 2258.55 | nM | 5.65 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 2723.79 | nM | 5.57 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 3266.08 | nM | 5.49 |
| CHEMBL1673039 | — | IC50 | = | 3824.03 | nM | 5.42 |
| CHEMBL1242367 | — | IC50 | = | 4555.08 | nM | 5.34 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 4831.76 | nM | 5.32 |
| CHEMBL591429 | PAC-1 | IC50 | = | 5359.47 | nM | 5.27 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 6007.53 | nM | 5.22 |
| CHEMBL535 | SUNITINIB | IC50 | = | 6125.19 | nM | 5.21 |
| CHEMBL2144069 | — | IC50 | = | 6519.35 | nM | 5.19 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 7522.72 | nM | 5.12 |
| CHEMBL2363137 | — | IC50 | = | 8238.43 | nM | 5.08 |
| CHEMBL191384 | — | IC50 | = | 8611.15 | nM | 5.07 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 10658.27 | nM | 4.97 |
| CHEMBL258844 | — | IC50 | = | 10893.86 | nM | 4.96 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 11393.72 | nM | 4.94 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 11770.4 | nM | 4.93 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 12487.15 | nM | 4.90 |
| CHEMBL209148 | — | IC50 | = | 13264.31 | nM | 4.88 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 13343.8 | nM | 4.88 |