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Assay Detail

CHEMBL2363318

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Functional
SANGER: Inhibition of human J82 cell growth in a cell viability assay.
ChEMBL ↗
95
Total Activities
94
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type J82
Confidence 1 — Organism
Curated By Autocuration

Target

J82 (CHEMBL614586) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 95 5.62 9.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL105 MITOMYCIN 4.0 1 9.92
CHEMBL94657 PATUPILONE 3.0 1 8.85
CHEMBL65 CAMPTOTHECIN -1.0 1 8.33
CHEMBL888 GEMCITABINE 4.0 1 8.13
CHEMBL96926 THAPSIGARGIN — 1 8.10
CHEMBL3545252 DOCETAXEL 4.0 1 7.86
CHEMBL1972860 ELESCLOMOL 3.0 1 7.85
CHEMBL53463 DOXORUBICIN 4.0 1 7.67
CHEMBL252164 LUMINESPIB 2.0 1 7.52
CHEMBL159 VINBLASTINE 4.0 1 7.16
CHEMBL553025 VINORELBINE 4.0 1 7.01
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.96
CHEMBL9470 SHIKONIN — 1 6.85
CHEMBL1201182 TEMSIROLIMUS 4.0 1 6.83
CHEMBL1879463 DACTOLISIB 3.0 1 6.73
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.68
CHEMBL109480 TANESPIMYCIN 3.0 1 6.56
CHEMBL2165191 AZD-6482 2.0 2 6.32
CHEMBL6067492 BLEOMYCIN 4.0 1 6.11
CHEMBL585951 — — 1 6.10
CHEMBL2041933 AZD-7762 1.0 1 6.09
CHEMBL1171837 PONATINIB 4.0 1 6.02
CHEMBL217354 — — 1 5.95
CHEMBL575448 BMS-754807 2.0 1 5.84
CHEMBL939 GEFITINIB 4.0 1 5.84
CHEMBL1190711 — — 1 5.82
CHEMBL803 CYTARABINE 4.0 1 5.79
CHEMBL477772 PAZOPANIB 4.0 1 5.69
CHEMBL2363137 — — 1 5.58
CHEMBL44657 ETOPOSIDE 4.0 1 5.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL105 MITOMYCIN IC50 = 0.119 nM 9.92
CHEMBL94657 PATUPILONE IC50 = 1.41 nM 8.85
CHEMBL65 CAMPTOTHECIN IC50 = 4.722 nM 8.33
CHEMBL888 GEMCITABINE IC50 = 7.41 nM 8.13
CHEMBL96926 THAPSIGARGIN IC50 = 7.91 nM 8.10
CHEMBL3545252 DOCETAXEL IC50 = 13.9 nM 7.86
CHEMBL1972860 ELESCLOMOL IC50 = 14.13 nM 7.85
CHEMBL53463 DOXORUBICIN IC50 = 21.34 nM 7.67
CHEMBL252164 LUMINESPIB IC50 = 30.07 nM 7.52
CHEMBL159 VINBLASTINE IC50 = 68.47 nM 7.16
CHEMBL553025 VINORELBINE IC50 = 97.79 nM 7.01
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 108.84 nM 6.96
CHEMBL9470 SHIKONIN IC50 = 142.55 nM 6.85
CHEMBL1201182 TEMSIROLIMUS IC50 = 148.03 nM 6.83
CHEMBL1879463 DACTOLISIB IC50 = 185.18 nM 6.73
CHEMBL449158 BRYOSTATIN 1 IC50 = 208.19 nM 6.68
CHEMBL109480 TANESPIMYCIN IC50 = 272.65 nM 6.56
CHEMBL2165191 AZD-6482 IC50 = 477.79 nM 6.32
CHEMBL6067492 BLEOMYCIN IC50 = 774.31 nM 6.11
CHEMBL585951 — IC50 = 800.11 nM 6.10
CHEMBL2041933 AZD-7762 IC50 = 804.87 nM 6.09
CHEMBL1171837 PONATINIB IC50 = 955.43 nM 6.02
CHEMBL217354 — IC50 = 1128.42 nM 5.95
CHEMBL575448 BMS-754807 IC50 = 1439.59 nM 5.84
CHEMBL939 GEFITINIB IC50 = 1457.66 nM 5.84
CHEMBL1190711 — IC50 = 1512.87 nM 5.82
CHEMBL803 CYTARABINE IC50 = 1618.02 nM 5.79
CHEMBL477772 PAZOPANIB IC50 = 2060.88 nM 5.69
CHEMBL2363137 — IC50 = 2620.61 nM 5.58
CHEMBL44657 ETOPOSIDE IC50 = 3339.87 nM 5.48
CHEMBL98 VORINOSTAT IC50 = 3505.7 nM 5.46
CHEMBL34259 METHOTREXATE IC50 = 4099.42 nM 5.39
CHEMBL289228 TIPIFARNIB IC50 = 4184.16 nM 5.38
CHEMBL1801204 AZD-8055 IC50 = 4334.41 nM 5.36
CHEMBL191384 — IC50 = 4339.88 nM 5.36
CHEMBL608533 MIDOSTAURIN IC50 = 4431.78 nM 5.35
CHEMBL603469 LESTAURTINIB IC50 = 4563.36 nM 5.34
CHEMBL11359 CISPLATIN IC50 = 5097.74 nM 5.29
CHEMBL472940 — IC50 = 7049.65 nM 5.15
CHEMBL135561 — IC50 = 7459.81 nM 5.13
CHEMBL558642 GSK-650394 IC50 = 8197.23 nM 5.09
CHEMBL521851 PICTILISIB IC50 = 8294.91 nM 5.08
CHEMBL1084546 PF-00562271 IC50 = 8341.24 nM 5.08
CHEMBL443684 NAVITOCLAX IC50 = 8900.38 nM 5.05
CHEMBL259181 — IC50 = 9508.08 nM 5.02
CHEMBL258844 — IC50 = 11250.35 nM 4.95
CHEMBL1023 BEXAROTENE IC50 = 11334.07 nM 4.95
CHEMBL221137 EMBELIN IC50 = 11827.31 nM 4.93
CHEMBL507361 MIRDAMETINIB IC50 = 14032.88 nM 4.85
CHEMBL1173655 AFATINIB IC50 = 15056.97 nM 4.82