Assay Detail
Functional
CHEMBL2363322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human JVM-3 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | JVM-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.53 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.77 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.63 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.60 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.40 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.89 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.79 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.53 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.51 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.47 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.64 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.54 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.54 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.53 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.33 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.27 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.20 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.16 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 6.07 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 5.98 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.91 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.84 |
| CHEMBL379975 | — | — | 1 | 5.84 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 5.83 |
| CHEMBL379300 | A-443654 | — | 1 | 5.83 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.78 |
| CHEMBL514499 | GW843682X | — | 1 | 5.73 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.73 |
| CHEMBL577784 | BX-795 | — | 1 | 5.73 |
| CHEMBL64925 | MG-132 | — | 2 | 5.71 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.705 | nM | 8.77 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.331 | nM | 8.63 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 2.504 | nM | 8.60 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 3.952 | nM | 8.40 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 12.99 | nM | 7.89 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 16.04 | nM | 7.79 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 29.22 | nM | 7.53 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 30.83 | nM | 7.51 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 33.65 | nM | 7.47 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 230.36 | nM | 6.64 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 285.92 | nM | 6.54 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 292.06 | nM | 6.54 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 292.81 | nM | 6.53 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 462.92 | nM | 6.33 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 541.17 | nM | 6.27 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 638.04 | nM | 6.20 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 700.6 | nM | 6.16 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 851.78 | nM | 6.07 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1050.17 | nM | 5.98 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1231.33 | nM | 5.91 |
| CHEMBL379975 | — | IC50 | = | 1431.06 | nM | 5.84 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1454.1 | nM | 5.84 |
| CHEMBL513909 | BI-2536 | IC50 | = | 1478.55 | nM | 5.83 |
| CHEMBL379300 | A-443654 | IC50 | = | 1478.98 | nM | 5.83 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1648.75 | nM | 5.78 |
| CHEMBL577784 | BX-795 | IC50 | = | 1864.91 | nM | 5.73 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1854.51 | nM | 5.73 |
| CHEMBL514499 | GW843682X | IC50 | = | 1881.07 | nM | 5.73 |
| CHEMBL64925 | MG-132 | IC50 | = | 1939.04 | nM | 5.71 |
| CHEMBL939 | GEFITINIB | IC50 | = | 2346.43 | nM | 5.63 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 2593.24 | nM | 5.59 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 2647.52 | nM | 5.58 |
| CHEMBL202721 | — | IC50 | = | 2747.83 | nM | 5.56 |
| CHEMBL573107 | — | IC50 | = | 3067.56 | nM | 5.51 |
| CHEMBL188678 | — | IC50 | = | 3480.77 | nM | 5.46 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 4182.22 | nM | 5.38 |
| CHEMBL3349342 | — | IC50 | = | 4379.4 | nM | 5.36 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 4606.18 | nM | 5.34 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 5250.14 | nM | 5.28 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 5300.22 | nM | 5.28 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 5723.25 | nM | 5.24 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 7895.99 | nM | 5.10 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 8152.68 | nM | 5.09 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 9569.99 | nM | 5.02 |
| CHEMBL300389 | — | IC50 | = | 9910.81 | nM | 5.00 |
| CHEMBL477989 | SB590885 | IC50 | = | 12092.85 | nM | 4.92 |
| CHEMBL393929 | — | IC50 | = | 14262.68 | nM | 4.85 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 14265.63 | nM | 4.85 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 15571.6 | nM | 4.81 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 18716.98 | nM | 4.73 |