Assay Detail
Functional
CHEMBL2363324
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SANGER: Inhibition of human K-562 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.43 | 9.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213100 | — | — | 1 | 9.79 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.39 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.16 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.82 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.27 |
| CHEMBL514499 | GW843682X | — | 1 | 7.23 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.04 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.96 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 6.65 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.51 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.48 |
| CHEMBL483847 | — | — | 1 | 6.44 |
| CHEMBL197603 | — | — | 1 | 6.41 |
| CHEMBL379300 | A-443654 | — | 1 | 6.41 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.41 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.36 |
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | 6.35 |
| CHEMBL300389 | — | — | 1 | 6.29 |
| CHEMBL2144069 | — | — | 1 | 6.18 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.17 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.11 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.97 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 5.97 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.86 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 5.83 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.81 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.78 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.77 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 5.76 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213100 | — | IC50 | = | 0.1617 | nM | 9.79 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 4.115 | nM | 8.39 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 6.886 | nM | 8.16 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 15.16 | nM | 7.82 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 53.87 | nM | 7.27 |
| CHEMBL514499 | GW843682X | IC50 | = | 59.4 | nM | 7.23 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 91.2 | nM | 7.04 |
| CHEMBL513909 | BI-2536 | IC50 | = | 108.58 | nM | 6.96 |
| CHEMBL941 | IMATINIB | IC50 | = | 224.32 | nM | 6.65 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 305.4 | nM | 6.51 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 332.98 | nM | 6.48 |
| CHEMBL483847 | — | IC50 | = | 360.93 | nM | 6.44 |
| CHEMBL197603 | — | IC50 | = | 391.82 | nM | 6.41 |
| CHEMBL379300 | A-443654 | IC50 | = | 385.36 | nM | 6.41 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 385.8 | nM | 6.41 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 434.72 | nM | 6.36 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 449.67 | nM | 6.35 |
| CHEMBL300389 | — | IC50 | = | 515.47 | nM | 6.29 |
| CHEMBL2144069 | — | IC50 | = | 666.95 | nM | 6.18 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 669.51 | nM | 6.17 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 770.24 | nM | 6.11 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1077.74 | nM | 5.97 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1082.28 | nM | 5.97 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1392.19 | nM | 5.86 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 1479.85 | nM | 5.83 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1539.82 | nM | 5.81 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1670.37 | nM | 5.78 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1714.19 | nM | 5.77 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 1722.69 | nM | 5.76 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 2008.98 | nM | 5.70 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1978.69 | nM | 5.70 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 3299.43 | nM | 5.48 |
| CHEMBL64925 | MG-132 | IC50 | = | 3991.8 | nM | 5.40 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 4738.14 | nM | 5.32 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 4823.17 | nM | 5.32 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 4875.06 | nM | 5.31 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 5903.6 | nM | 5.23 |
| CHEMBL401930 | — | IC50 | = | 7812.27 | nM | 5.11 |
| CHEMBL515416 | — | IC50 | = | 8087.24 | nM | 5.09 |
| CHEMBL105442 | CI-1040 | IC50 | = | 8839.57 | nM | 5.05 |
| CHEMBL939 | GEFITINIB | IC50 | = | 10839.53 | nM | 4.96 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 11019.12 | nM | 4.96 |
| CHEMBL1673039 | — | IC50 | = | 11526.28 | nM | 4.94 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 11724.77 | nM | 4.93 |
| CHEMBL535 | SUNITINIB | IC50 | = | 11870.23 | nM | 4.93 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 14574.68 | nM | 4.84 |
| CHEMBL259181 | — | IC50 | = | 15026.28 | nM | 4.82 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 15814.01 | nM | 4.80 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 16738.44 | nM | 4.78 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 18631.69 | nM | 4.73 |