Assay Detail
Functional
CHEMBL2363330
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SANGER: Inhibition of human KARPAS-45 cell growth in a cell viability assay.
125
Total Activities
124
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KARPAS-45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 125 | 5.87 | 10.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 10.50 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.75 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.45 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.24 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.23 |
| CHEMBL514499 | GW843682X | — | 1 | 8.21 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.19 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.09 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.90 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.87 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.78 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.57 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 7.47 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.29 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.28 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.27 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 7.11 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.03 |
| CHEMBL300389 | — | — | 1 | 6.98 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.91 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.87 |
| CHEMBL1090090 | VX-702 | 2.0 | 1 | 6.83 |
| CHEMBL573107 | — | — | 1 | 6.78 |
| CHEMBL512504 | — | — | 1 | 6.77 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.77 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.76 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.55 |
| CHEMBL379300 | A-443654 | — | 1 | 6.53 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 6.43 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 0.03172 | nM | 10.50 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.793 | nM | 8.75 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 3.542 | nM | 8.45 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5.735 | nM | 8.24 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 5.818 | nM | 8.23 |
| CHEMBL514499 | GW843682X | IC50 | = | 6.125 | nM | 8.21 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 6.518 | nM | 8.19 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 8.059 | nM | 8.09 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 13.51 | nM | 7.87 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 16.71 | nM | 7.78 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 26.8 | nM | 7.57 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 33.71 | nM | 7.47 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 51.34 | nM | 7.29 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 52.42 | nM | 7.28 |
| CHEMBL513909 | BI-2536 | IC50 | = | 53.58 | nM | 7.27 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 78.15 | nM | 7.11 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 93.45 | nM | 7.03 |
| CHEMBL300389 | — | IC50 | = | 103.74 | nM | 6.98 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 123.89 | nM | 6.91 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 134.47 | nM | 6.87 |
| CHEMBL1090090 | VX-702 | IC50 | = | 148.26 | nM | 6.83 |
| CHEMBL573107 | — | IC50 | = | 165.25 | nM | 6.78 |
| CHEMBL512504 | — | IC50 | = | 169.84 | nM | 6.77 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 168.47 | nM | 6.77 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 173.89 | nM | 6.76 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 278.33 | nM | 6.55 |
| CHEMBL379300 | A-443654 | IC50 | = | 295.7 | nM | 6.53 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 373.21 | nM | 6.43 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 376.16 | nM | 6.42 |
| CHEMBL202721 | — | IC50 | = | 381.28 | nM | 6.42 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 378.62 | nM | 6.42 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 489.33 | nM | 6.31 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 647.6 | nM | 6.19 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 764.22 | nM | 6.12 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 782.35 | nM | 6.11 |
| CHEMBL585951 | — | IC50 | = | 795.06 | nM | 6.10 |
| CHEMBL509032 | TAE-684 | IC50 | = | 842.63 | nM | 6.07 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 924.66 | nM | 6.03 |
| CHEMBL64925 | MG-132 | IC50 | = | 1040.16 | nM | 5.98 |
| CHEMBL3349342 | — | IC50 | = | 1140.04 | nM | 5.94 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1267.63 | nM | 5.90 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1694.34 | nM | 5.77 |
| CHEMBL1190711 | — | IC50 | = | 1901.37 | nM | 5.72 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 2049.78 | nM | 5.69 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 2026.54 | nM | 5.69 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 2082.48 | nM | 5.68 |
| CHEMBL939 | GEFITINIB | IC50 | = | 2124.79 | nM | 5.67 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 2271.84 | nM | 5.64 |
| CHEMBL535 | SUNITINIB | IC50 | = | 2494.46 | nM | 5.60 |