Assay Detail
Functional
CHEMBL2363338
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SANGER: Inhibition of human KM12 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KM12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.73 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.90 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.65 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.58 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.39 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.20 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.87 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.87 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.85 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.84 |
| CHEMBL514499 | GW843682X | — | 1 | 7.78 |
| CHEMBL401930 | — | — | 1 | 7.55 |
| CHEMBL512504 | — | — | 1 | 7.49 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.42 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.29 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.24 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.20 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.12 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.12 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.04 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 7.03 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 7.01 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.93 |
| CHEMBL300389 | — | — | 1 | 6.91 |
| CHEMBL379300 | A-443654 | — | 1 | 6.85 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.78 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.69 |
| CHEMBL585951 | — | — | 1 | 6.67 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.66 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.63 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 1.272 | nM | 8.90 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 2.236 | nM | 8.65 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 2.606 | nM | 8.58 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 4.081 | nM | 8.39 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.373 | nM | 8.20 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 13.44 | nM | 7.87 |
| CHEMBL513909 | BI-2536 | IC50 | = | 13.48 | nM | 7.87 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 13.99 | nM | 7.85 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 14.42 | nM | 7.84 |
| CHEMBL514499 | GW843682X | IC50 | = | 16.46 | nM | 7.78 |
| CHEMBL401930 | — | IC50 | = | 28.44 | nM | 7.55 |
| CHEMBL512504 | — | IC50 | = | 32.13 | nM | 7.49 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 37.8 | nM | 7.42 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 51.58 | nM | 7.29 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 57.22 | nM | 7.24 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 63.48 | nM | 7.20 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 74.99 | nM | 7.12 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 76.4 | nM | 7.12 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 91.49 | nM | 7.04 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 92.75 | nM | 7.03 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 97.37 | nM | 7.01 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 116.86 | nM | 6.93 |
| CHEMBL300389 | — | IC50 | = | 123.74 | nM | 6.91 |
| CHEMBL379300 | A-443654 | IC50 | = | 140.89 | nM | 6.85 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 164.44 | nM | 6.78 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 204.31 | nM | 6.69 |
| CHEMBL585951 | — | IC50 | = | 211.99 | nM | 6.67 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 218.15 | nM | 6.66 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 235.7 | nM | 6.63 |
| CHEMBL105442 | CI-1040 | IC50 | = | 240.57 | nM | 6.62 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 263.6 | nM | 6.58 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 318.3 | nM | 6.50 |
| CHEMBL535 | SUNITINIB | IC50 | = | 350.14 | nM | 6.46 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 385.57 | nM | 6.41 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 623.0 | nM | 6.21 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 706.9 | nM | 6.15 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 739.71 | nM | 6.13 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 850.69 | nM | 6.07 |
| CHEMBL64925 | MG-132 | IC50 | = | 854.66 | nM | 6.07 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 878.0 | nM | 6.06 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 1020.98 | nM | 5.99 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1083.64 | nM | 5.96 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 1476.64 | nM | 5.83 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1647.0 | nM | 5.78 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1797.41 | nM | 5.75 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1816.02 | nM | 5.74 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1879.38 | nM | 5.73 |
| CHEMBL217354 | — | IC50 | = | 1882.5 | nM | 5.72 |
| CHEMBL176544 | — | IC50 | = | 1937.25 | nM | 5.71 |
| CHEMBL2144069 | — | IC50 | = | 2081.03 | nM | 5.68 |