Assay Detail
Functional
CHEMBL2363341
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SANGER: Inhibition of human KNS-42 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KNS-42 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.36 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.59 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.41 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.39 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.10 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.05 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.77 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.73 |
| CHEMBL514499 | GW843682X | — | 1 | 7.61 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.48 |
| CHEMBL64925 | MG-132 | — | 2 | 7.35 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.09 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.09 |
| CHEMBL300389 | — | — | 1 | 6.88 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.84 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.62 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.62 |
| CHEMBL379300 | A-443654 | — | 1 | 6.61 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.56 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.40 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.31 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.23 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.13 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.10 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.96 |
| CHEMBL585951 | — | — | 1 | 5.96 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 5.91 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.88 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.73 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.62 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.2579 | nM | 9.59 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 3.915 | nM | 8.41 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 4.115 | nM | 8.39 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 8.028 | nM | 8.10 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 8.907 | nM | 8.05 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 16.89 | nM | 7.77 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 18.69 | nM | 7.73 |
| CHEMBL514499 | GW843682X | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 33.14 | nM | 7.48 |
| CHEMBL64925 | MG-132 | IC50 | = | 44.41 | nM | 7.35 |
| CHEMBL513909 | BI-2536 | IC50 | = | 81.61 | nM | 7.09 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 82.03 | nM | 7.09 |
| CHEMBL300389 | — | IC50 | = | 130.2 | nM | 6.88 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 144.3 | nM | 6.84 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 242.83 | nM | 6.62 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 242.67 | nM | 6.62 |
| CHEMBL379300 | A-443654 | IC50 | = | 248.2 | nM | 6.61 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 272.93 | nM | 6.56 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 400.45 | nM | 6.40 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 489.74 | nM | 6.31 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 586.81 | nM | 6.23 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 735.82 | nM | 6.13 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 788.31 | nM | 6.10 |
| CHEMBL585951 | — | IC50 | = | 1086.01 | nM | 5.96 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1092.39 | nM | 5.96 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 1244.12 | nM | 5.91 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1302.96 | nM | 5.88 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1862.66 | nM | 5.73 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2391.05 | nM | 5.62 |
| CHEMBL217354 | — | IC50 | = | 2544.28 | nM | 5.59 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 2581.98 | nM | 5.59 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL573107 | — | IC50 | = | 5261.6 | nM | 5.28 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 5325.42 | nM | 5.27 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 5762.12 | nM | 5.24 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 6781.97 | nM | 5.17 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 8746.84 | nM | 5.06 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 8819.15 | nM | 5.05 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 8930.18 | nM | 5.05 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 9434.07 | nM | 5.03 |
| CHEMBL191384 | — | IC50 | = | 11004.33 | nM | 4.96 |
| CHEMBL554 | LAPATINIB | IC50 | = | 11725.55 | nM | 4.93 |
| CHEMBL2363137 | — | IC50 | = | 12688.77 | nM | 4.90 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 12877.09 | nM | 4.89 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 12991.83 | nM | 4.89 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 12998.41 | nM | 4.89 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 13651.06 | nM | 4.87 |
| CHEMBL1242367 | — | IC50 | = | 14748.04 | nM | 4.83 |
| CHEMBL1673039 | — | IC50 | = | 15833.94 | nM | 4.80 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 16727.38 | nM | 4.78 |