Assay Detail
Functional
CHEMBL2363344
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SANGER: Inhibition of human KOSC-2 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KOSC-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.57 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.59 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.16 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.55 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.36 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.26 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.39 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.16 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.13 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.78 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.75 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.61 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.60 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.49 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.40 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.37 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 6.33 |
| CHEMBL217354 | — | — | 1 | 6.30 |
| CHEMBL585951 | — | — | 1 | 6.28 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.20 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.19 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.18 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.97 |
| CHEMBL573107 | — | — | 1 | 5.95 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 5.88 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.83 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.82 |
| CHEMBL3349342 | — | — | 1 | 5.78 |
| CHEMBL2137530 | SERDEMETAN | 2.0 | 1 | 5.69 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 5.63 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.2546 | nM | 9.59 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.6975 | nM | 9.16 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 2.833 | nM | 8.55 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 4.393 | nM | 8.36 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 5.453 | nM | 8.26 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 41.1 | nM | 7.39 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 69.97 | nM | 7.16 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 74.57 | nM | 7.13 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 166.96 | nM | 6.78 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 177.34 | nM | 6.75 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 246.71 | nM | 6.61 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 248.71 | nM | 6.60 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 326.76 | nM | 6.49 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 400.1 | nM | 6.40 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 425.01 | nM | 6.37 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 466.9 | nM | 6.33 |
| CHEMBL217354 | — | IC50 | = | 495.74 | nM | 6.30 |
| CHEMBL585951 | — | IC50 | = | 531.14 | nM | 6.28 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 637.21 | nM | 6.20 |
| CHEMBL803 | CYTARABINE | IC50 | = | 643.09 | nM | 6.19 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 658.36 | nM | 6.18 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1080.21 | nM | 5.97 |
| CHEMBL573107 | — | IC50 | = | 1133.85 | nM | 5.95 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1317.75 | nM | 5.88 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1490.84 | nM | 5.83 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1531.03 | nM | 5.82 |
| CHEMBL3349342 | — | IC50 | = | 1676.18 | nM | 5.78 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 2032.17 | nM | 5.69 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 2353.38 | nM | 5.63 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 2342.93 | nM | 5.63 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2560.76 | nM | 5.59 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 2638.79 | nM | 5.58 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 2905.16 | nM | 5.54 |
| CHEMBL577784 | BX-795 | IC50 | = | 3072.48 | nM | 5.51 |
| CHEMBL393929 | — | IC50 | = | 3446.62 | nM | 5.46 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 3834.51 | nM | 5.42 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 4399.28 | nM | 5.36 |
| CHEMBL939 | GEFITINIB | IC50 | = | 4999.59 | nM | 5.30 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 9628.34 | nM | 5.02 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 11148.3 | nM | 4.95 |
| CHEMBL105442 | CI-1040 | IC50 | = | 11622.23 | nM | 4.93 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 12550.77 | nM | 4.90 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 13349.49 | nM | 4.88 |
| CHEMBL379975 | — | IC50 | = | 16368.21 | nM | 4.79 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 16112.48 | nM | 4.79 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 17675.69 | nM | 4.75 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 18774.58 | nM | 4.73 |
| CHEMBL399530 | — | IC50 | = | 20255.33 | nM | 4.69 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 22316.34 | nM | 4.65 |
| CHEMBL202721 | — | IC50 | = | 23243.46 | nM | 4.63 |