Assay Detail
Functional
CHEMBL2363345
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SANGER: Inhibition of human KP-4 cell growth in a cell viability assay.
95
Total Activities
94
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KP-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 95 | 5.66 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.17 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.81 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.66 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.62 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.58 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.57 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.50 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.25 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 8.15 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.44 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.39 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.32 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.03 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.94 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.56 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.38 |
| CHEMBL217354 | — | — | 1 | 6.34 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.30 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.27 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.25 |
| CHEMBL585951 | — | — | 1 | 6.24 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.21 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.16 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.86 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.83 |
| CHEMBL2363137 | — | — | 1 | 5.78 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.78 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.68 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.66 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.6818 | nM | 9.17 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.563 | nM | 8.81 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 2.173 | nM | 8.66 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 2.369 | nM | 8.62 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 2.641 | nM | 8.58 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 2.711 | nM | 8.57 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 5.611 | nM | 8.25 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 6.996 | nM | 8.15 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 36.63 | nM | 7.44 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 40.77 | nM | 7.39 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 47.53 | nM | 7.32 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 93.15 | nM | 7.03 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 115.63 | nM | 6.94 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 276.46 | nM | 6.56 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 416.15 | nM | 6.38 |
| CHEMBL217354 | — | IC50 | = | 454.97 | nM | 6.34 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 500.8 | nM | 6.30 |
| CHEMBL803 | CYTARABINE | IC50 | = | 535.74 | nM | 6.27 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 567.73 | nM | 6.25 |
| CHEMBL585951 | — | IC50 | = | 576.69 | nM | 6.24 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 615.85 | nM | 6.21 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 695.73 | nM | 6.16 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1370.85 | nM | 5.86 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1461.51 | nM | 5.83 |
| CHEMBL2363137 | — | IC50 | = | 1655.27 | nM | 5.78 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1653.04 | nM | 5.78 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2103.12 | nM | 5.68 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2170.66 | nM | 5.66 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 2307.87 | nM | 5.64 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 3154.03 | nM | 5.50 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 4493.05 | nM | 5.35 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 5188.55 | nM | 5.29 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 5463.34 | nM | 5.26 |
| CHEMBL393929 | — | IC50 | = | 5698.23 | nM | 5.24 |
| CHEMBL379975 | — | IC50 | = | 6444.22 | nM | 5.19 |
| CHEMBL191384 | — | IC50 | = | 6430.72 | nM | 5.19 |
| CHEMBL202721 | — | IC50 | = | 7492.54 | nM | 5.12 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 8418.53 | nM | 5.08 |
| CHEMBL939 | GEFITINIB | IC50 | = | 9488.38 | nM | 5.02 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 10183.21 | nM | 4.99 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 11749.81 | nM | 4.93 |
| CHEMBL259181 | — | IC50 | = | 13156.32 | nM | 4.88 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 13622.64 | nM | 4.87 |
| CHEMBL210618 | — | IC50 | = | 19108.71 | nM | 4.72 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 19853.08 | nM | 4.70 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 21434.44 | nM | 4.67 |
| CHEMBL105442 | CI-1040 | IC50 | = | 21119.63 | nM | 4.67 |
| CHEMBL577784 | BX-795 | IC50 | = | 28743.19 | nM | 4.54 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 29516.02 | nM | 4.53 |