Assay Detail
Functional
CHEMBL2363349
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SANGER: Inhibition of human KS-1 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KS-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.99 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.47 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.84 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.83 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.76 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 8.61 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.46 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.44 |
| CHEMBL220241 | GSK-269962A | — | 1 | 8.34 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.23 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.10 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.07 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 7.96 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.87 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.86 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.86 |
| CHEMBL300389 | — | — | 1 | 7.86 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.80 |
| CHEMBL514499 | GW843682X | — | 1 | 7.57 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.56 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 7.42 |
| CHEMBL9470 | SHIKONIN | — | 1 | 7.38 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.35 |
| CHEMBL379300 | A-443654 | — | 1 | 7.27 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.24 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.20 |
| CHEMBL64925 | MG-132 | — | 2 | 7.19 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.17 |
| CHEMBL213100 | — | — | 1 | 7.11 |
| CHEMBL401930 | — | — | 1 | 6.99 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.3402 | nM | 9.47 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.441 | nM | 8.84 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1.466 | nM | 8.83 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.759 | nM | 8.76 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 2.454 | nM | 8.61 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 3.443 | nM | 8.46 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 3.615 | nM | 8.44 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 4.598 | nM | 8.34 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 5.816 | nM | 8.23 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 7.987 | nM | 8.10 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 8.59 | nM | 8.07 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 10.84 | nM | 7.96 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 13.55 | nM | 7.87 |
| CHEMBL300389 | — | IC50 | = | 13.96 | nM | 7.86 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 13.92 | nM | 7.86 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 13.78 | nM | 7.86 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 15.94 | nM | 7.80 |
| CHEMBL514499 | GW843682X | IC50 | = | 26.64 | nM | 7.57 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 27.3 | nM | 7.56 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 38.35 | nM | 7.42 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 41.5 | nM | 7.38 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 44.66 | nM | 7.35 |
| CHEMBL379300 | A-443654 | IC50 | = | 53.54 | nM | 7.27 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 57.87 | nM | 7.24 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 63.46 | nM | 7.20 |
| CHEMBL64925 | MG-132 | IC50 | = | 64.58 | nM | 7.19 |
| CHEMBL513909 | BI-2536 | IC50 | = | 67.48 | nM | 7.17 |
| CHEMBL213100 | — | IC50 | = | 77.58 | nM | 7.11 |
| CHEMBL401930 | — | IC50 | = | 102.49 | nM | 6.99 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 130.06 | nM | 6.89 |
| CHEMBL585951 | — | IC50 | = | 159.09 | nM | 6.80 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 166.52 | nM | 6.78 |
| CHEMBL509032 | TAE-684 | IC50 | = | 193.43 | nM | 6.71 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 237.85 | nM | 6.62 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 305.26 | nM | 6.51 |
| CHEMBL217354 | — | IC50 | = | 321.78 | nM | 6.49 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 334.44 | nM | 6.48 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 364.15 | nM | 6.44 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 367.42 | nM | 6.43 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 375.3 | nM | 6.43 |
| CHEMBL2144069 | — | IC50 | = | 393.37 | nM | 6.41 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 451.72 | nM | 6.34 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 466.03 | nM | 6.33 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 770.35 | nM | 6.11 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 842.04 | nM | 6.08 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 880.96 | nM | 6.05 |
| CHEMBL64925 | MG-132 | IC50 | = | 971.75 | nM | 6.01 |
| CHEMBL197603 | — | IC50 | = | 1031.06 | nM | 5.99 |
| CHEMBL515416 | — | IC50 | = | 1046.54 | nM | 5.98 |
| CHEMBL209148 | — | IC50 | = | 1208.73 | nM | 5.92 |