Assay Detail
Functional
CHEMBL2363350
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SANGER: Inhibition of human KU-19-19 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KU-19-19 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.40 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.15 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.66 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.51 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.36 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.20 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.10 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.97 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.64 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.58 |
| CHEMBL3349342 | — | — | 1 | 6.44 |
| CHEMBL217354 | — | — | 1 | 6.36 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.30 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.29 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.19 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.11 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.07 |
| CHEMBL2137530 | SERDEMETAN | 2.0 | 1 | 6.03 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.97 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.96 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 5.95 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.88 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 5.80 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.70 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.64 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.60 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 5.50 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.50 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 5.47 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.47 |
| CHEMBL573107 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 7.094 | nM | 8.15 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 22.03 | nM | 7.66 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 31.13 | nM | 7.51 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 43.72 | nM | 7.36 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 63.61 | nM | 7.20 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 108.17 | nM | 6.97 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 228.39 | nM | 6.64 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 265.16 | nM | 6.58 |
| CHEMBL3349342 | — | IC50 | = | 365.93 | nM | 6.44 |
| CHEMBL217354 | — | IC50 | = | 440.31 | nM | 6.36 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 505.29 | nM | 6.30 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 516.07 | nM | 6.29 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 645.86 | nM | 6.19 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 774.64 | nM | 6.11 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 851.21 | nM | 6.07 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 932.36 | nM | 6.03 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1077.52 | nM | 5.97 |
| CHEMBL939 | GEFITINIB | IC50 | = | 1085.41 | nM | 5.96 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1115.05 | nM | 5.95 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1325.22 | nM | 5.88 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1598.52 | nM | 5.80 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 2003.72 | nM | 5.70 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2269.17 | nM | 5.64 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2535.13 | nM | 5.60 |
| CHEMBL105442 | CI-1040 | IC50 | = | 3170.34 | nM | 5.50 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 3183.07 | nM | 5.50 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 3419.51 | nM | 5.47 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 3358.35 | nM | 5.47 |
| CHEMBL573107 | — | IC50 | = | 3603.04 | nM | 5.44 |
| CHEMBL188678 | — | IC50 | = | 4329.21 | nM | 5.36 |
| CHEMBL803 | CYTARABINE | IC50 | = | 4428.91 | nM | 5.35 |
| CHEMBL399530 | — | IC50 | = | 4464.92 | nM | 5.35 |
| CHEMBL512504 | — | IC50 | = | 4567.29 | nM | 5.34 |
| CHEMBL585951 | — | IC50 | = | 5099.62 | nM | 5.29 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 6017.31 | nM | 5.22 |
| CHEMBL379975 | — | IC50 | = | 6222.5 | nM | 5.21 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 7164.76 | nM | 5.14 |
| CHEMBL577784 | BX-795 | IC50 | = | 8487.51 | nM | 5.07 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 10104.56 | nM | 5.00 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 14687.71 | nM | 4.83 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 15020.86 | nM | 4.82 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 16812.35 | nM | 4.77 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 18960.82 | nM | 4.72 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 22024.23 | nM | 4.66 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 21898.17 | nM | 4.66 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 22169.67 | nM | 4.65 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 26103.05 | nM | 4.58 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 28492.22 | nM | 4.54 |
| CHEMBL2134202 | — | IC50 | = | 28994.99 | nM | 4.54 |