Assay Detail
Functional
CHEMBL2363354
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SANGER: Inhibition of human KYSE-140 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KYSE-140 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.78 | 10.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 10.03 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.03 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.91 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 8.36 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.69 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.68 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.62 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.55 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.35 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.30 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.30 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.16 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.08 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.88 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.81 |
| CHEMBL217354 | — | — | 1 | 6.73 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.68 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.43 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.42 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.35 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.16 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.11 |
| CHEMBL585951 | — | — | 1 | 5.98 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.96 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.94 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.91 |
| CHEMBL191384 | — | — | 1 | 5.85 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.81 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 5.75 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.09243 | nM | 10.03 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.9328 | nM | 9.03 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.226 | nM | 8.91 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 4.349 | nM | 8.36 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 20.24 | nM | 7.69 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 20.99 | nM | 7.68 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 23.84 | nM | 7.62 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 27.91 | nM | 7.55 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 44.94 | nM | 7.35 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 50.42 | nM | 7.30 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 50.55 | nM | 7.30 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 69.74 | nM | 7.16 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 83.3 | nM | 7.08 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 130.41 | nM | 6.88 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 155.73 | nM | 6.81 |
| CHEMBL217354 | — | IC50 | = | 186.43 | nM | 6.73 |
| CHEMBL939 | GEFITINIB | IC50 | = | 209.96 | nM | 6.68 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 373.93 | nM | 6.43 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 381.34 | nM | 6.42 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 449.21 | nM | 6.35 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 686.85 | nM | 6.16 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 781.68 | nM | 6.11 |
| CHEMBL585951 | — | IC50 | = | 1053.16 | nM | 5.98 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1108.28 | nM | 5.96 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1144.44 | nM | 5.94 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1245.29 | nM | 5.91 |
| CHEMBL191384 | — | IC50 | = | 1408.15 | nM | 5.85 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1557.41 | nM | 5.81 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1756.55 | nM | 5.75 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2116.19 | nM | 5.67 |
| CHEMBL803 | CYTARABINE | IC50 | = | 2752.6 | nM | 5.56 |
| CHEMBL3349342 | — | IC50 | = | 2896.21 | nM | 5.54 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 2871.57 | nM | 5.54 |
| CHEMBL1190711 | — | IC50 | = | 3745.2 | nM | 5.43 |
| CHEMBL577784 | BX-795 | IC50 | = | 3721.56 | nM | 5.43 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 3896.03 | nM | 5.41 |
| CHEMBL2363137 | — | IC50 | = | 4582.43 | nM | 5.34 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 4917.46 | nM | 5.31 |
| CHEMBL591429 | PAC-1 | IC50 | = | 4963.67 | nM | 5.30 |
| CHEMBL221137 | EMBELIN | IC50 | = | 5038.94 | nM | 5.30 |
| CHEMBL105442 | CI-1040 | IC50 | = | 6021.82 | nM | 5.22 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 7440.61 | nM | 5.13 |
| CHEMBL259181 | — | IC50 | = | 7489.19 | nM | 5.13 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 7588.36 | nM | 5.12 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 8090.78 | nM | 5.09 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 12159.64 | nM | 4.92 |
| CHEMBL379975 | — | IC50 | = | 12950.86 | nM | 4.89 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 12859.48 | nM | 4.89 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 14075.34 | nM | 4.85 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 14632.66 | nM | 4.83 |