Assay Detail
Functional
CHEMBL2363359
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SANGER: Inhibition of human KYSE-450 cell growth in a cell viability assay.
98
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KYSE-450 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 98 | 5.77 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.57 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 9.33 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.11 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.84 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.20 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.02 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.01 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.87 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.62 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.41 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.35 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.26 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.22 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.86 |
| CHEMBL217354 | — | — | 1 | 6.76 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.68 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.61 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.56 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.48 |
| CHEMBL585951 | — | — | 1 | 6.48 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.26 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.25 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.19 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.14 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.08 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.01 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.98 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.96 |
| CHEMBL191384 | — | — | 1 | 5.94 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.2674 | nM | 9.57 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 0.469 | nM | 9.33 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.7766 | nM | 9.11 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.432 | nM | 8.84 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 6.315 | nM | 8.20 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 9.649 | nM | 8.02 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 9.741 | nM | 8.01 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 13.49 | nM | 7.87 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 23.73 | nM | 7.62 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 38.97 | nM | 7.41 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 44.71 | nM | 7.35 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 55.16 | nM | 7.26 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 59.78 | nM | 7.22 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 138.15 | nM | 6.86 |
| CHEMBL217354 | — | IC50 | = | 175.34 | nM | 6.76 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 208.9 | nM | 6.68 |
| CHEMBL939 | GEFITINIB | IC50 | = | 247.92 | nM | 6.61 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 273.29 | nM | 6.56 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 334.47 | nM | 6.48 |
| CHEMBL585951 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 546.64 | nM | 6.26 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 563.11 | nM | 6.25 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 652.24 | nM | 6.19 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 728.85 | nM | 6.14 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 827.25 | nM | 6.08 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 986.26 | nM | 6.01 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1053.36 | nM | 5.98 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1090.59 | nM | 5.96 |
| CHEMBL191384 | — | IC50 | = | 1143.66 | nM | 5.94 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 1934.24 | nM | 5.71 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2138.43 | nM | 5.67 |
| CHEMBL1190711 | — | IC50 | = | 2321.75 | nM | 5.63 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 2592.02 | nM | 5.59 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3685.82 | nM | 5.43 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3688.71 | nM | 5.43 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 3969.97 | nM | 5.40 |
| CHEMBL202721 | — | IC50 | = | 4960.42 | nM | 5.30 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 5599.45 | nM | 5.25 |
| CHEMBL2363137 | — | IC50 | = | 6373.38 | nM | 5.20 |
| CHEMBL573107 | — | IC50 | = | 7637.91 | nM | 5.12 |
| CHEMBL259181 | — | IC50 | = | 8471.05 | nM | 5.07 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 8710.12 | nM | 5.06 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 8865.48 | nM | 5.05 |
| CHEMBL3349342 | — | IC50 | = | 9860.28 | nM | 5.01 |
| CHEMBL105442 | CI-1040 | IC50 | = | 11405.65 | nM | 4.94 |
| CHEMBL399530 | — | IC50 | = | 13061.66 | nM | 4.88 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 13039.65 | nM | 4.88 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 14888.19 | nM | 4.83 |
| CHEMBL221137 | EMBELIN | IC50 | = | 17716.09 | nM | 4.75 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 18380.9 | nM | 4.74 |