Assay Detail
Functional
CHEMBL2363360
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SANGER: Inhibition of human KYSE-510 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KYSE-510 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.79 | 10.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 10.13 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 9.83 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.45 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.08 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 8.63 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.38 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.23 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.17 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.84 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.81 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.33 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.18 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.04 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.96 |
| CHEMBL217354 | — | — | 1 | 6.65 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.60 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.56 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.51 |
| CHEMBL585951 | — | — | 1 | 6.35 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.29 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.26 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.26 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.25 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.11 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.01 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.80 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 5.74 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.73 |
| CHEMBL558642 | GSK-650394 | — | 1 | 5.67 |
| CHEMBL258844 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.07379 | nM | 10.13 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 0.1486 | nM | 9.83 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.3529 | nM | 9.45 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.8402 | nM | 9.08 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 2.329 | nM | 8.63 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 4.188 | nM | 8.38 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 5.875 | nM | 8.23 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 6.754 | nM | 8.17 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 14.42 | nM | 7.84 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 15.48 | nM | 7.81 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 46.49 | nM | 7.33 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 65.75 | nM | 7.18 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 91.72 | nM | 7.04 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 110.35 | nM | 6.96 |
| CHEMBL217354 | — | IC50 | = | 222.34 | nM | 6.65 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 252.7 | nM | 6.60 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 275.05 | nM | 6.56 |
| CHEMBL803 | CYTARABINE | IC50 | = | 306.33 | nM | 6.51 |
| CHEMBL585951 | — | IC50 | = | 447.34 | nM | 6.35 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 517.55 | nM | 6.29 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 554.7 | nM | 6.26 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 543.47 | nM | 6.26 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 566.39 | nM | 6.25 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 785.39 | nM | 6.11 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 977.1 | nM | 6.01 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1582.5 | nM | 5.80 |
| CHEMBL591429 | PAC-1 | IC50 | = | 1831.5 | nM | 5.74 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 1857.49 | nM | 5.73 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 2130.91 | nM | 5.67 |
| CHEMBL258844 | — | IC50 | = | 2211.01 | nM | 5.66 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 2649.85 | nM | 5.58 |
| CHEMBL939 | GEFITINIB | IC50 | = | 2867.86 | nM | 5.54 |
| CHEMBL1190711 | — | IC50 | = | 2866.15 | nM | 5.54 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2895.04 | nM | 5.54 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 3109.95 | nM | 5.51 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 3384.36 | nM | 5.47 |
| CHEMBL259181 | — | IC50 | = | 3448.62 | nM | 5.46 |
| CHEMBL202721 | — | IC50 | = | 3636.47 | nM | 5.44 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3721.81 | nM | 5.43 |
| CHEMBL573107 | — | IC50 | = | 4260.9 | nM | 5.37 |
| CHEMBL399530 | — | IC50 | = | 4482.33 | nM | 5.35 |
| CHEMBL2363137 | — | IC50 | = | 4836.86 | nM | 5.32 |
| CHEMBL577784 | BX-795 | IC50 | = | 4958.4 | nM | 5.30 |
| CHEMBL379975 | — | IC50 | = | 5013.65 | nM | 5.30 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 5511.0 | nM | 5.26 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 5795.81 | nM | 5.24 |
| CHEMBL221137 | EMBELIN | IC50 | = | 5809.49 | nM | 5.24 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 7084.32 | nM | 5.15 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 8136.04 | nM | 5.09 |
| CHEMBL191384 | — | IC50 | = | 8605.77 | nM | 5.07 |